RAGNO Rino

Professore associato
Settore Scientifico-Disciplinare: 
CHIM/08
Settore concorsuale: 
03/D1
Informazioni personali
Curriculum vitae (it): 
Curriculum vitae (en): 

Rino Ragno è Professore Associato della Facoltà di Farmacia e Medicina di Sapienza Università di Roma, dove si è laureato con lode nel 1989 in Chimica e Tecnologia Farmaceutiche svolgendo una tesi sperimentale in chimica farmaceutica di sintesi sotto la guida del prof. Silvio Massa. Dal 1990 al 2000 ha lavorato come assistente nei laboratori di ricerca chimico-farmaceutica del prof. Marino Artico eseguendo progetti inerenti la sintesi di molecole ad attività antifungina, antitubercolare ed antivirale. Nel 1992 il prof. Ragno ha anche acquisito la laurea in Farmacia diplomandosi con lode. Dal 1990 il Prof. Rino Ragno ha iniziato ad interessarsi di progettazione chimico farmaceutica tramite l’ausilio del calcolatore. Ha così frequentato numerosi corsi di perfezionamento sulla chimica computazionale con particolare riguardo all’applicazione nella chimica farmaceutica. Nel 1996 e nel 1998 ha trascorso due anni a St Louis in Missouri nei laboratori del prof Garland R. Marshall dove ha completato la sua formazione nel campo della chimica farmaceutica computazionale.

Dal 2000 ha iniziato un laboratorio di progettazione chimico-farmaceutica chiamato RCMD (Rome Center for Molecular Design, http://www.rcmd.it)

Nel 2010, 2012 e 2014 e' stato visting professor a Metz (Francia) ospitato nei laboratoridiretti dal Professeur Emérite Gilbert KIRSCH UMR CNRS 7053 L2CM Université de Lorraine.

Il Prof Rino Ragno dal 2001 ha fatto da relatore a oltre 110 tesi sperimentali e ha svolto la funzione di Tutor a diversi studenti del dottorato in Scienze Farmaceutiche di cui e' anche parte del collegio dei docenti.

Nel periodo più recente il Prof. Rino Ragno ha focalizzato la sua ricerca nei seguenti principali campi: 

(1) progettazione e sintesi di nuovi composti bioattivi.

(2) Estrazione, caratterizzazione chimica e biologica di composti di origine naturale con particolare riferimento agli oli essenziali.

(3) Progettazione e realizzazione di portali scientifici (www.3d-qsar.com) di utilità scientifica e didattica.

(4) Elaborazione dati mediante metodi machine learning con codice sviluppato in house

Infine come membro della Facoltà di Farmacia e Medicina dal 2000 a tutt’oggi il Prof. Rino Ragno è incaricato dell’insegnamento di corsi nel settore scientifico disciplinare CHIM08 sia in lauree di I° livello (Biotecnologie, Scienze Farmaceutiche Applicate), specialistiche (Biotecnologie Farmaceutiche e Chimica e Tecnologia Farmaceutiche), scuole di specializzazione e dottorati di ricerca.

Nel 2016 il Prof. Rino Ragno ha iniziato una StartUp universitaria dal nome Alchemical Dynamics con l'obiettivo di applicare l'esperienza maturata in oltre 25 anni di ricerca.

Dal 2015 e' incaricato di coordinare il gruppo tecnico di Ateneo per la registrazione di corsi di insegnamento online chiamati MOOC

Nel 2017 ha conseguito l'abilitazione nazionale per la prima fascia per il settore consorsuale 03/D1

Il Prof. Rino Ragno è co-autore di oltre 134 articoli scientifici "peer reviewed" su riviste internazionali ad alto valore di fattore di impatto, un brevetto nazionale, due brevetti internazionali e oltre 120 comunicazioni poster/orali a convegni nazionali ed internazionali.

Didattica
Aree di afferenza: 
- Area Farmaceutica
- Corso di Laurea in Biotecnologie
- Corso di Laurea in Chimica e Tecnologia Farmaceutiche
- Corso di Laurea Specialistica in Biotecnologie Farmaceutiche
Ricevimento studenti: 

Tutti i giorni dalle 08:00 alle 09:00 previo appuntamento per e-mail a rino.ragno@uniroma1.it.

Disponibilità tesi: 

Ogni anno sono disponibili 2-3 posti di tesi sperimentale nell'ambito:

1) Chimica Farmaceutica Computazionale e Progettazione Farmaci. 

2) Estrazione di Composti di Origine Naturale con Particolare Riferimento agli Oli Essenziali. 

Ricerca
Aree di interesse: 
  • Chimica Farmaceutica
  • Machine Learning
  • Drug Design
  • Bioinformatica
  • Estrazione di Composti di Origine Naturale con Particolare Riferimento agli Oli Essenziali

 

Pubblicazioni
Pubblicazioni: 

Nei seguenti link e' possibile visualizzare la lista delle pubblicazioni recensitee in siti istituzionali e dai motori di ricerca internazionali

Pubblicazioni scientifiche

Anno: 2021
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models Cell Death Discovery 2021 Sci_Dir
The anti-STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death FEBS Journal 2021 Sci_Dir
Anno: 2020
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene Human Genetics 2020 Sci_Dir
Antimicrobial essential oil formulation: Chitosan coated nanoemulsions for nose to brain delivery Pharmaceutics 2020 Sci_Dir
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6 Molecules 2020 Sci_Dir
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7 Molecules 2020 Sci_Dir
Chemical composition and antimicrobial activity of essential oil of Helichrysum italicum (Roth) G. Don fil. (Asteraceae) from Montenegro Natural Product Research 2020 Sci_Dir
Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization ACS Chemical Biology 2020 Sci_Dir
Essential oils against bacterial isolates from cystic fibrosis patients by means of antimicrobial and unsupervised machine learning approaches Scientific Reports 2020 Sci_Dir
Essential oils and their main chemical components: The past 20 years of preclinical studies in Melanoma Cancers 2020 Sci_Dir
Essential oils biofilm modulation activity, chemical and machine learning analysis. Application on staphylococcus aureus isolates from cystic fibrosis patients International Journal of Molecular Sciences 2020 Sci_Dir
Experimental data based machine learning classification models with predictive ability to select in vitro active antiviral and non-toxic essential oils Molecules 2020 Sci_Dir
Gas-phase structures and thermochemical properties of protonated 5-HMF isomers International Journal of Mass Spectrometry 2020 Sci_Dir
Identification of inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes International Journal of Molecular Sciences 2020 Sci_Dir
Potent in vitro activity of citrus aurantium essential oil and vitis vinifera hydrolate against gut yeast isolates from irritable bowel syndrome patients—the right mix for potential therapeutic use Nutrients 2020 Sci_Dir
Teaching and Learning Computational Drug Design: Student Investigations of 3D Quantitative Structure-Activity Relationships through Web Applications Journal of Chemical Education 2020 Sci_Dir
Variation in essential oil content and composition of Ridolfia segetum Moris based on 30-hour prolonged fractionated extraction procedure Natural Product Research 2020 Sci_Dir
Anno: 2019
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4 Molecules 2019 Sci_Dir
Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5 Molecules 2019 Sci_Dir
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells European Journal of Medicinal Chemistry 2019 Sci_Dir
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: Effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype Clinical Epigenetics 2019 Sci_Dir
Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones Journal of Medicinal Chemistry 2019 Sci_Dir
In-vitro evaluation of different antimicrobial combinations with and without colistin against carbapenem-resistant Acinetobacter baumannii Molecules 2019 Sci_Dir
Machine Learning Analyses on Data including Essential Oil Chemical Composition and In Vitro Experimental Antibiofilm Activities against Staphylococcus Species Molecules 2019 Sci_Dir
Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism Cells 2019 Sci_Dir
www.3d-qsar.com: a web portal that brings 3-D QSAR to all electronic devices—the Py-CoMFA web application as tool to build models from pre-aligned datasets Journal of Computer-Aided Molecular Design 2019 Sci_Dir
Anno: 2018
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Ab-initio and experimental study of pentose sugar dehydration mechanism in the gas phase Carbohydrate Research 2018 Sci_Dir
Antimicrobial and antibiofilm activity and machine learning classification analysis of essential oils from different mediterranean plants against pseudomonas aeruginosa Molecules 2018 Sci_Dir
Breakthroughs in medicinal chemistry: New targets and mechanisms; new drugs; new hopes–2 Molecules 2018 Sci_Dir
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches Journal of Computer-Aided Molecular Design 2018 Sci_Dir
Lycium barbarum polysaccharides: Extraction; purification; structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review Food Chemistry 2018 Sci_Dir
Melissa officinalis L. subsp. altissima (Sibth. & Sm.) Arcang. essential oil: Chemical composition and preliminary antimicrobial investigation of samples obtained at different harvesting periods and by fractionated extractions Industrial Crops and Products 2018 Sci_Dir
RIP1–HAT1–SIRT complex identification and targeting in treatment and prevention of cancer Clinical Cancer Research 2018 Sci_Dir
Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood; a new chemotype from Montenegro Natural Product Research 2018 Sci_Dir
The targeted pesticides as acetylcholinesterase inhibitors: Comprehensive cross-organism molecular modelling studies performed to anticipate the pharmacology of harmfulness to humans in vitro Molecules 2018 Sci_Dir
The targeted pesticides as acetylcholinesterase inhibitors: Comprehensive cross-organism molecular modelling studies performed to anticipate the pharmacology of harmfulness to humans in vitro Molecules 2018 Sci_Dir
Anno: 2017
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Breakthroughs in medicinal chemistry: New targets and mechanisms; new drugs; new hopes Molecules 2017 Sci_Dir
Calamintha nepeta (L.) Savi and its main essential oil constituent pulegone: Biological activities and chemistry Molecules 2017 Sci_Dir
Chemical and antimicrobial analyses of Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood; an endemic of the Western Balkan Molecules 2017 Sci_Dir
Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation European Journal of Medicinal Chemistry 2017 Sci_Dir
Esential oils extraction: a 24-hour steam distillation systematic methodology Natural Product Research 2017 Sci_Dir
Essential oil extraction; chemical analysis and anti-candida activity of calamintha nepeta (L.) Savi subsp. glandulosa (Req.) ball-new approaches Molecules 2017 Sci_Dir
Exploring the first Rimonabant analog-opioid peptide hybrid compound; as bivalent ligand for CB1 and opioid receptors Journal of Enzyme Inhibition and Medicinal Chemistry 2017 Sci_Dir
Genotoxicity assessment of piperitenone oxide: An in vitro and in silico evaluation Food and Chemical Toxicology 2017 Sci_Dir
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells European Journal of Medicinal Chemistry 2017 Sci_Dir
Synthesis; biological evaluation and quantitative structure-active relationships of 1;3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity European Journal of Medicinal Chemistry 2017 Sci_Dir
Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure-Activity Relationships Predictive Models Journal of Chemical Information and Modeling 2017 Sci_Dir
Anno: 2016
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis; Biological Evaluation; and Docking Analysis ChemMedChem 2016 Sci_Dir
Antibacterial activity of essential oils mixture against PSA Natural Product Research 2016 Sci_Dir
New Inhibitors of Indoleamine 2;3-Dioxygenase 1: Molecular Modeling Studies; Synthesis; and Biological Evaluation Journal of Medicinal Chemistry 2016 Sci_Dir
Structure-Based Modeling of Histone Deacetylases Inhibitors Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes 2016 Sci_Dir
Anno: 2015
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Binding of azole drugs to heme: A combined MS/MS and computational approach Polyhedron 2015 Sci_Dir
Effects of mentha suaveolens essential oil on chlamydia trachomatis BioMed Research International 2015 Sci_Dir
Mentha suaveolens Ehrh. (Lamiaceae) essential oil and its main constituent piperitenone oxide: Biological activities and chemistry Molecules 2015 Sci_Dir
Multidisciplinary approach to determine the optimal time and period for extracting the essential oil from mentha suaveolens ehrh Molecules 2015 Sci_Dir
Synthesis; biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors Bioorganic and Medicinal Chemistry 2015 Sci_Dir
Vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors: Development and validation of predictive 3-D QSAR models through extensive ligand- and structure-based approaches Journal of Computer-Aided Molecular Design 2015 Sci_Dir
Anno: 2014
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation Bioorganic and Medicinal Chemistry 2014 Sci_Dir
Effects of mentha suaveolens essential oil alone or in combination with other drugs in candida albicans Evidence-based Complementary and Alternative Medicine 2014 Sci_Dir
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3 H)-ones: Effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes Journal of Medicinal Chemistry 2014 Sci_Dir
Hsp90 inhibitors; part 1: Definition of 3-D QSAutogrid/R models as a tool for virtual screening Journal of Chemical Information and Modeling 2014 Sci_Dir
Hsp90 inhibitors; part 2: Combining ligand-based and structure-based approaches for virtual screening application Journal of Chemical Information and Modeling 2014 Sci_Dir
In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide Phytomedicine 2014 Sci_Dir
Anno: 2013
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring European Journal of Medicinal Chemistry 2013 Sci_Dir
Design; synthesis and biological evaluation of new classes of thieno[3;2-d]pyrimidinone and thieno[1;2;3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) European Journal of Medicinal Chemistry 2013 Sci_Dir
Pharmacophore assessment through 3-D QSAR: Evaluation of the predictive ability on new derivatives by the application on a series of antitubercular agents Journal of Chemical Information and Modeling 2013 Sci_Dir
Anno: 2012
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
2-(Alkyl/Aryl)amino-6-benzylpyrimidin-4(3 H)-ones as inhibitors of wild-type and mutant HIV-1: Enantioselectivity studies Journal of Medicinal Chemistry 2012 Sci_Dir
3-D QSAutogrid/R: An alternative procedure to build 3-D QSAR models. methodologies and applications Journal of Chemical Information and Modeling 2012 Sci_Dir
Comprehensive model of wild-type and mutant HIV-1 reverse transciptases Journal of Computer-Aided Molecular Design 2012 Sci_Dir
Gas-phase basicity of 2-furaldehyde Journal of Mass Spectrometry 2012 Sci_Dir
Histone deacetylase inhibitors: Structure-based modeling and isoform-selectivity prediction Journal of Chemical Information and Modeling 2012 Sci_Dir
Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives European Journal of Medicinal Chemistry 2012 Sci_Dir
Anno: 2011
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection BMC Complementary and Alternative Medicine 2011 Sci_Dir
Identification of glutathione-methacrylates adducts in gingival fibroblasts and erythrocytes by HPLC-MS and capillary electrophoresis Dental Materials 2011 Sci_Dir
Identification of Small-Molecule Inhibitors of the XendoU Endoribonucleases Family ChemMedChem 2011 Sci_Dir
Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity ChemMedChem 2011 Sci_Dir
Anno: 2010
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Combining 3-D quantitative structure-activity relationship with ligand based and structure based alignment procedures for in silico screening of new hepatitis c virus NS5B polymerase inhibitors Journal of Chemical Information and Modeling 2010 Sci_Dir
Design; synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1) ChemMedChem 2010 Sci_Dir
Letter: In vitro activity of mentha suaveolens essential oil against cryptococcus neoformans and dermatophytes International Journal of Essential Oil Therapeutics 2010
Anno: 2009
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Antimycotic activity of Achillea ageratum L. essential oil International Journal of Essential Oil Therapeutics 2009
New pyrrole-based histone deacetylase inhibitors: Binding mode; enzyme- and cell-based investigations International Journal of Biochemistry and Cell Biology 2009 Sci_Dir
Small-molecule interferon inducers. Toward the comprehension of the molecular determinants through ligand-based approaches Journal of Chemical Information and Modeling 2009 Sci_Dir
Anno: 2008
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones; a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure - Activity relationship profile Journal of Medicinal Chemistry 2008 Sci_Dir
Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR; homology and docking studies European Journal of Medicinal Chemistry 2008 Sci_Dir
CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors Bioorganic and Medicinal Chemistry 2008 Sci_Dir
In vitro activity of essential oil of Myrtus communis L. against Candida albicans International Journal of Essential Oil Therapeutics 2008
The tumor marker human placental protein 11 is an endoribonuclease Journal of Biological Chemistry 2008 Sci_Dir
Anno: 2007
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: Docking and 3D QSAR studies Expert Opinion on Drug Discovery 2007 Sci_Dir
Small molecule inhibitors of histone arginine methyltransferases: Homology modeling; molecular docking; binding mode analysis; and biological evaluations Journal of Medicinal Chemistry 2007 Sci_Dir
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains Journal of Medicinal Chemistry 2007 Sci_Dir
Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors ChemMedChem 2007 Sci_Dir
Anno: 2006
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
3-D QSAR studies on histone deacetylase inhibitors. A GOLPE/GRID approach on different series of compounds Journal of Chemical Information and Modeling 2006 Sci_Dir
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1; a polyanionic compound endowed with anti-HIV-1 activity Journal of Chemical Information and Modeling 2006 Sci_Dir
Aroyl-pyrrolyl hydroxyamides: Influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition ChemMedChem 2006 Sci_Dir
Design; molecular modeling; synthesis; and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide Journal of Medicinal Chemistry 2006 Sci_Dir
Design; synthesis; biological evaluation; and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors ChemMedChem 2006 Sci_Dir
Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: Synthesis; biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide Antiviral Chemistry and Chemotherapy 2006 Sci_Dir
Synthesis and biological properties of novel; uracil-containing histone deacetylase inhibitors Journal of Medicinal Chemistry 2006 Sci_Dir
Anno: 2005
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
5-Alkyl-2-alkylamino-6-(2;6-difluorophenylalkyl)-3;4-dihydropyrimidin-4(3H) -ones; a new series of potent; broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family Bioorganic and Medicinal Chemistry 2005 Sci_Dir
Design; synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity Farmaco 2005 Sci_Dir

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