Pubblicazioni scientifiche

Anno: 2021
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Emerging Therapeutic Potential of SIRT6 Modulators Journal of Medicinal Chemistry 2021 Sci_Dir
Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer Cancers 2021 Sci_Dir
SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes Cells 2021 Sci_Dir
The two-faced role of sirt6 in cancer Cancers 2021 Sci_Dir
Anno: 2020
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CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas Frontiers in Pharmacology 2020 Sci_Dir
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment Biochemical Pharmacology 2020 Sci_Dir
Epigenetic polypharmacology: A new frontier for epi-drug discovery Medicinal Research Reviews 2020 Sci_Dir
From PARP1 to TNKS2 inhibition: A structure-based approach ACS Medicinal Chemistry Letters 2020 Sci_Dir
Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors Topics in Medicinal Chemistry 2020 Sci_Dir
Identification of inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes International Journal of Molecular Sciences 2020 Sci_Dir
Lysine Acetyltransferase Inhibitors From Natural Sources Frontiers in Pharmacology 2020 Sci_Dir
Pharmacological inhibition of lysine-specific demethylase 1 (Lsd1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in schistosoma mansoni PLoS Neglected Tropical Diseases 2020 Sci_Dir
Radioguided surgery with β − radiation in pancreatic Neuroendocrine Tumors: a feasibility study Scientific Reports 2020 Sci_Dir
Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs) European Journal of Medicinal Chemistry 2020 Sci_Dir
Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer Frontiers in Oncology 2020 Sci_Dir
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 Expert Opinion on Therapeutic Patents 2020 Sci_Dir
Targeting histone acetylation/deacetylation in parasites: an update (2017–2020) Current Opinion in Chemical Biology 2020 Sci_Dir
The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line Frontiers in Oncology 2020 Sci_Dir
Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation ChemMedChem 2020 Sci_Dir
Anno: 2019
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells eEuropean Journal of Pharmacology 2019 Sci_Dir
Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones Journal of Medicinal Chemistry 2019 Sci_Dir
Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells Chemotherapy 2019 Sci_Dir
Enzymatic and biological characterization of novel sirtuin modulators against cancer International Journal of Molecular Sciences 2019 Sci_Dir
Gold nanoparticles and nanorods in nuclear medicine: A mini review Applied Sciences (Switzerland) 2019 Sci_Dir
H19-dependent transcriptional regulation of β3 and β4 integrins upon estrogen and hypoxia favors metastatic potential in prostate cancer International Journal of Molecular Sciences 2019 Sci_Dir
Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis Clinical Epigenetics 2019 Sci_Dir
Identification of novel quinazoline derivatives as potent antiplasmodial agents European Journal of Medicinal Chemistry 2019 Sci_Dir
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer Cancers 2019 Sci_Dir
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2) Journal of Medicinal Chemistry 2019 Sci_Dir
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis Journal of Enzyme Inhibition and Medicinal Chemistry 2019 Sci_Dir
α-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors ACS Medicinal Chemistry Letters 2019 Sci_Dir
Anno: 2018
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches Journal of Computer-Aided Molecular Design 2018 Sci_Dir
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 Clinical Epigenetics 2018 Sci_Dir
Lysine acetyltransferase inhibitors: Structure-activity relationships and potential therapeutic implications Future Medicinal Chemistry 2018 Sci_Dir
Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative β− tracer suitable in radio-guided surgery Journal of Pharmaceutical and Biomedical Analysis 2018 Sci_Dir
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells Cell Death and Disease 2018 Sci_Dir
RIP1–HAT1–SIRT complex identification and targeting in treatment and prevention of cancer Clinical Cancer Research 2018 Sci_Dir
Anno: 2017
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability Journal of Enzyme Inhibition and Medicinal Chemistry 2017 Sci_Dir
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features Nature Communications 2017 Sci_Dir
Development of 1;2;4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure�Activity Relationship; X-ray Crystal Structure; and Anticancer Activity Journal of Medicinal Chemistry 2017 Sci_Dir
Feasibility of beta-particle radioguided surgery for a variety of “nuclear medicine” radionuclides Physica Medica 2017 Sci_Dir
Lysine Deacetylase Inhibitors in Parasites: Past; Present; and Future Perspectives Journal of Medicinal Chemistry 2017 Sci_Dir
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma Scientific Reports 2017 Sci_Dir
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules Angewandte Chemie - International Edition 2017 Sci_Dir
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis Oncotarget 2017 Sci_Dir
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor European Journal of Medicinal Chemistry 2017 Sci_Dir
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity Bioorganic and Medicinal Chemistry 2017 Sci_Dir
Y3+ embedded in polymeric nanoparticles: Morphology; dimension and stability of composite colloidal system Colloids and Surfaces A: Physicochemical and Engineering Aspects 2017 Sci_Dir
Anno: 2016
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At Long Last Potent and Selective KDM5 Inhibitors Cell Chemical Biology 2016 Sci_Dir
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition Journal of Translational Medicine 2016 Sci_Dir
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells Oncotarget 2016 Sci_Dir
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features Science Advances 2016 Sci_Dir
Sirtuin functions and modulation: from chemistry to the clinic Clinical Epigenetics 2016 Sci_Dir
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases Biochemical Pharmacology 2016 Sci_Dir
Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells American Journal of Cancer Research 2016
Anno: 2015
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A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts Oncotarget 2015
Enzyme kinetics and inhibition of histone acetyltransferase KAT8 European Journal of Medicinal Chemistry 2015 Sci_Dir
Novel histone deacetylase inhibitors induce growth arrest; apoptosis; and differentiation in sarcoma cancer stem cells Journal of Medicinal Chemistry 2015 Sci_Dir
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells MedChemComm 2015 Sci_Dir
SIRT5 regulation of ammonia-induced autophagy and mitophagy Autophagy 2015 Sci_Dir
Targeting Lysine Deacetylases (KDACs) in Parasites PLoS Neglected Tropical Diseases 2015 Sci_Dir
Anno: 2014
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib Biochemical Pharmacology 2014 Sci_Dir
Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392 Cancer Research 2014 Sci_Dir
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies European Journal of Medicinal Chemistry 2014 Sci_Dir
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3 H)-ones: Effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes Journal of Medicinal Chemistry 2014 Sci_Dir
IκB kinase ε targets interferon regulatory factor 1 in activated T lymphocytes Molecular and Cellular Biology 2014 Sci_Dir
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities Journal of Medicinal Chemistry 2014 Sci_Dir
Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity PLoS ONE 2014 Sci_Dir
Quinoline-based p300 histone acetyltransferase inhibitors with Pro-apoptotic activity in human leukemia U937 cells ChemMedChem 2014 Sci_Dir
Sirtuin modulators control reactive gliosis in an in vitro model of alzheimer's disease Frontiers in Pharmacology 2014 Sci_Dir
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases European Journal of Medicinal Chemistry 2014 Sci_Dir
Anno: 2013
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Inhibition of class i histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue Diabetes 2013 Sci_Dir
PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage PLoS ONE 2013 Sci_Dir
Anno: 2012
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2-(Alkyl/Aryl)amino-6-benzylpyrimidin-4(3 H)-ones as inhibitors of wild-type and mutant HIV-1: Enantioselectivity studies Journal of Medicinal Chemistry 2012 Sci_Dir
6-(Arylmethyl)pyrimidin-4(3H)-ones: Anthology and prospects of highly efficient anti-HIV agents Russian Chemical Bulletin 2012 Sci_Dir
An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 jumonji demethylases Journal of Molecular Biology 2012 Sci_Dir
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells Journal of Medicinal Chemistry 2012 Sci_Dir
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies ChemMedChem 2012 Sci_Dir
Discovery of salermide-related sirtuin inhibitors: Binding mode studies and antiproliferative effects in cancer cells including cancer stem cells Journal of Medicinal Chemistry 2012 Sci_Dir
P300/CBP-associated factor selectively regulates the extinction of conditioned fear Journal of Neuroscience 2012 Sci_Dir
Anno: 2011
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A photoreactive small-molecule probe for 2-oxoglutarate oxygenases Chemistry and Biology 2011 Sci_Dir
Biological Effects of MC2050; a Quinazoline-Based PARP-1 Inhibitor; in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells ChemMedChem 2011 Sci_Dir
Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: New; wide-spectrum anti-HIV-1 agents active at (Sub)-nanomolar level Journal of Medicinal Chemistry 2011 Sci_Dir
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3′-C-methyladenosine in leukaemia cells International Journal of Oncology 2011 Sci_Dir
Modulation of cell differentiation; proliferation; and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors Journal of Medicinal Chemistry 2011 Sci_Dir
Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions Chemical Communications 2011 Sci_Dir
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile Bioorganic and Medicinal Chemistry 2011 Sci_Dir
Targeting histone demethylases: A new avenue for the fight against cancer Genes and Cancer 2011 Sci_Dir
Anno: 2010
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About the specific character of the reaction of 2-thioxo-2;3- dihydropyrimidin-4(1H)-one derivatives with iodomethane and alkyl(chloromethyl) sulfides Khimiya Geterotsiklicheskikh Soedinenii 2010
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues Journal of Medicinal Chemistry 2010 Sci_Dir
Evaluation of histone deacetylases as drug targets in Huntington's disease models PLoS Currents 2010 Sci_Dir
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation Journal of Molecular Endocrinology 2010 Sci_Dir
Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors ChemMedChem 2010 Sci_Dir
Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: Potential therapeutic implications in a mouse model of hindlimb ischemia Stem Cells 2010 Sci_Dir
Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment Proteomics - Clinical Applications 2010 Sci_Dir
The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice Cardiovascular Research 2010 Sci_Dir
The specific character of the reaction of derivatives of 2-thioxo-2;3-dihydropyrimidin-4(1H)-one with iodomethane and alkyl chloromethyl sulfides Chemistry of Heterocyclic Compounds 2010 Sci_Dir
Anno: 2009
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"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence Retrovirology 2009 Sci_Dir
Chiral HPLC separation and absolute configuration of novel S-DABO derivatives Chirality 2009 Sci_Dir
Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise Current Pharmaceutical Design 2009 Sci_Dir

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