Pubblicazioni scientifiche

Anno: 2009

  1. Stereoselective synthesis of 2-substituted 6-[1-(2;6-difluorophenyl)ethyl]- 5-methylpyrimidin-4(3H)-ones
    Pubblicato su: Russian Journal of Organic Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Chiral HPLC separation and absolute configuration of novel S-DABO derivatives
    Pubblicato su: Chirality
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Salermide; a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
    Pubblicato su: Oncogene
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases
    Pubblicato su: Bioorganic and Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Salermide; a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect (Oncogene (2009) 28; (781-791) DOI: 10.1038/onc.2008.436)
    Pubblicato su: Oncogene
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  6. Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise
    Pubblicato su: Current Pharmaceutical Design
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  7. Non-cancer uses of histone deacetylase inhibitors: Effects on infectious diseases and β-hemoglobinopathies
    Pubblicato su: Current Topics in Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2008

  1. Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR; homology and docking studies
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. 5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones; a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure - Activity relationship profile
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities
    Pubblicato su: Bioorganic and Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases
    Pubblicato su: Bioorganic and Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  6. Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling
    Pubblicato su: Circulation Research
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  7. Histone deacetylase inhibitors and hemoglobin F induction in β-thalassemia
    Pubblicato su: International Journal of Biochemistry and Cell Biology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2007

  1. Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Slow-; tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Histone deacetylase inhibitors may reduce pathogenicity and virulence in Candida albicans
    Pubblicato su: FEMS Yeast Research
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans
    Pubblicato su: Bioorganic and Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia
    Pubblicato su: Molecular Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  6. Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity
    Pubblicato su: International Journal of Biochemistry and Cell Biology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2006

  1. Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity
    Pubblicato su: Arkivoc
    - Vedi su: 'Scopus'
  2. Synthesis and biological properties of novel; uracil-containing histone deacetylase inhibitors
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. 6-Alkylthio-4-[1-(2;6-difluorophenyl)alkyl]-1H-[1;3;5]triazin-2-ones (ADATs): Novel regulators of cell differentiation and proliferation
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Analytical and semipreparative high performance liquid chromatography separation of stereoisomers of novel 3;4-dihydropyrimidin-4(3H)-one derivatives on the immobilised amylose-based Chiralpak IA chiral stationary phase
    Pubblicato su: Journal of Separation Science
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  6. One-pot; high-yielding synthesis of novel dihydrothiazolo[3;2-a] pyrimidinones
    Pubblicato su: Synthetic Communications
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2005

  1. Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. 6-[1-(2;6-Difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. A novel Gcn5p inhibitor represses cell growth; gene transcription and histone acetylation in budding yeast
    Pubblicato su: Biochemical Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Histone deacetylation in epigenetics: An attractive target for anticancer therapy
    Pubblicato su: Medicinal Research Reviews
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Exploring the connection unit in the HDAC inhibitor pharmacophore model: Novel uracil-based hydroxamates
    Pubblicato su: Bioorganic and Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2003

  1. Discovery of (Aryloxopropenyl)pyrrolyl Hydroxyamides as Selective Inhibitors of Class IIa Histone Deacetylase Homologue HD1-A
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

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