BOTTA Bruno

Professore ordinario
Settore Scientifico-Disciplinare: 
CHIM/06

    COST Action 'CM 1407'

COST Action CM 1407 Chair of the Action: prof. Bruno BOTTA

 

Informazioni personali

Bruno Botta è nato nel 1954 e si è laureato in Chimica nel 1977 presso l’Università degli Studi di Roma “La Sapienza”. Dal 1981 al 1992 è stato ricercatore universitario presso l'Università Cattolica di Roma. Dal 1984 al 1985 ha svolto un periodo di post-dottorato presso il Dipartimento di Chimica della University of British Columbia (UBC, Vancouver, Canada) lavorando sulla sintesi e biosintesi di alcaloidi antitumorali della famiglia della vinblastina-vincristina. Nel 1992 diventa Professore Associato di Chimica Organica presso la Facoltà di Farmacia dell’Università degli Studi di Roma “La Sapienza” e dal 2001 è Professore Ordinario. Dal 2011 è Direttore del Dipartimento di Chimica e Tecnologie del Farmaco presso l’Università degli Studi di Roma “La Sapienza”. Dal 15 Novembre del 2014 è Pro Rettore all’Internazionalizzazione presso l’Università di Roma La Sapienza. Il 16 Marzo 2015 è stato nominato Chair della Azione Cost 1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery".
E’ stato invitato a tenere conferenze nelle seguenti università: Michigan State University (USA), Wofford College Spartanburg (USA), The Scripps Research Institute, La Jolla (USA), University of British Columbia (Vancouver, Canada), Universidad de Montevideo (Uruguay), Stanford University (USA), Universidade Federal de Pernambuco (Brasile), Toho University, Chiba, Tokyo (Japan). E’ autore di 150 pubblicazioni, di cui 5 brevetti (2 nazionali e 3 internazionali - USA e Europa). Inoltre è autore di 10 libri e curatore di due testi didattici di Chimica Organica per la casa editrice Edi-Ermes. 


Bruno Botta was born in 1954 and got his Laurea in Chemistry in 1977 at "Sapienza" University of Rome. During the years 1984-1985, he was appointed as postdoctoral associate at the Department of Chemistry of the University of British Columbia (UBC, Vancouver, Canada) working on the synthesis and biosynthesis of clinically important anticancer alkaloids of the vinblastine-vincristine family. From 1981 to 1992 he was appointed as assistant professor (ricercatore) at the Catholic University of Rome. From 1992 to 2001 he was appointed as associate professor of organic chemistry at "Sapienza" University of Rome (Faculty of Pharmacy) and became full professor at the same University in 2001. Since 2011, he is Head of the Dipartimento di Chimica e Tecnologie del Farmaco and in November 2014 he has been nominated Deputy Provost for the Internationalization of the University of Rome "La Sapienza”. Since March 16 2015, he is Chair of the Cost Action CM-1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery".
He was invited to give lectures in the following universities: Michigan State University (USA), Wofford College Spartanburg (SC, USA), The Scripps Research Institute, La Jolla (CA, USA), University of British Columbia (Vancouver, Canada), Universidad de Montevideo (Uruguay), Stanford University (CA, USA), Universidade Federal de Pernambuco (Brazil), Toho University, Chiba, Tokyo (Japan).
He is author of 150 publications, including 5 patents (3 national and 2 international – USA and Europe), and, beside that, he is author and co-author of 10 books. For the Italian publishing house Edi-Ermes he edited 2 text books of Organic Chemistry.


 

Didattica
Aree di afferenza: 
- Area Farmaceutica
- Corso di Laurea in Farmacia
Disponibilità tesi: 
  1. Sintesi e caratterizzazione di recettori artificiali e loro impiego nel riconoscimento molecolare e nel drug-delivery
  2. Isolamento, determinazione della struttura e sintesi di principi attivi con attività antitumorale presenti negli estratti di piante medicinali
Ricerca
Finanziamenti: 

Il Professor Botta è stato coordinatore dei seguenti progetti:

  • British American Tobacco (2005-2009) “Surface-Linked Resorc[4]arenes for the Entrapping of Nitrogen Oxides”, 256.000 €. 
  • FIRB (2003-2007) Strategic National Program “Enzymes and catalysers for biotransformation and sustainable chemistry” 150.000 €. 

  • Fondazione Roma (2009-2011) “Targeting signaling pathways involved in stem cell self-renewal and differentiation: basic and translational aspects”, 108.900 €. 

  • Regione Lazio (2007-2010) Riqualificazione e ammodernamento Laboratorio: “Tecnologie avanzate per la produzione dei farmaci”, 230.000 €. 

  • FIRB FARMCHIMNET (2007-2010) “Sintesi, caratterizzazione biologica e farmacologia di nuove molecole organiche, bioorganiche e naturali con attività antidegenerativa”, 70.000 €. 

  • FIRST (2007-2010) “Individuazione, caratterizzazione e valutazione preliminare dell'efficacia di strategie farmaceutiche innovative”, 90.000 €.

Aree di interesse: 
  • La prima linea di ricerca ha consentito di isolare e sintetizzare alcuni composti biologicamente attivi, quali dei guanidoderivati ad attività ipotensiva. Le reazioni di biotrasformazione sono state condotte utilizzando enzimi vegetali purificati (perossidasi e preniltrsferasi). Le perossidasi sono state impiegate in studi di cinetica enzimatica utilizzando dei substrati sintetici che rappresentano i precursori diretti di molecole ad alto valore aggiunto (quale ad esempio il Vepesid o Etoposid).

  • La seconda linea di ricerca ha permesso di mettere a punto un nuovo procedimento sintetico per ottenere dei macrocicli noti con il nome di resorc[4]areni. Sono stati preparati anche dei resorcareni chirali (impiegati in studi di enantiodiscriminazione in fase gassosa e in soluzione) e dei “resorcareni-capped” porfinici (impiegati in studi di incapsulamento di ioni cobalto).

Pubblicazioni
Pubblicazioni: 

Selected publications (2004-2014)

  • F. Ghirga; D. Quaglio; V. Iovine; B. Botta; M. Pierini, L. Mannina; A. P. Sobolev; F. Ugozzoli; I. D' Acquarica (2014). Synthesis of a Double-Spanned-Resorc[4]arene via Ring-Closing Metathesis and Calculation of Aggregation Propensity. J. Org. Chem. 10  [doi: 10.1021/jo502056v].
  • I. D' Acquarica; A. Calcaterra; F. Sacco; F. Balzano; F. Aiello; A. Tafi; N. Pesci; G. Uccello-Barretta; B. Botta (2013). Stereochemical Preference of 2'-Deoxycytidine for Chiral Bis(diamido)-bridged Basket Resorcin[4]arenes. Chirality
  • F. Ghirga; I. D'Acquarica; G. Delle Monache; L. Mannina; C. Molinaro; L. Nevola; A. P. Sobolev; M. Pierini; B. Botta (2013). Reaction of nitrosonium cation with resorc[4]arenes activated by supramolecular control: covalent bond formation. J. Org. Chem. 78, 6935-6946.
  • A. Cerreto; F. Corrente; B. Botta; S. Pacelli; P. Paolicelli; L. Mannina; M. A. Casadei (2013). NMR Characterization of Carboxymethyl Scleroglucan. Int. J. Polymer Anal. Charact. 18.
  • A. Filippi; C. Fraschetti; S. Piccirillo; F. Rondino; B. Botta; I. D'Acquarica; A. Calcaterra; M. Speranza (2012). Chirality Effects on the IRMPD Spectra of Basket Resorcinarene/Nucleoside Complexes. Chemistry 18, 8320-8328.
  • A. Marcone; M. Fontana; M. Barba; B. Botta; M. Nardini; F. Ghirga; A. Calcaterra; L. Pecci; R. M. Matarese (2011). Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review. Int. J. Mol. Sciences 12 3072-3084.
  • I. D'Acquarica; A. Cerreto; G. Delle Monache; F. Subrizi; A. Boffi; A. Tafi; S. Forli; B. Botta (2011). N-Linked Peptidoresorc[4]arene-Based Receptors as Noncompetitive Inhibitors for α-Chymotrypsin. J. Org. Chem. 76, 4396-4407.

  • B. Botta; C. Fraschetti; I. D'Acquarica; F. Sacco; J. Mattay; M. C. Letzel; M. Speranza (2011). Unprecedented gas-phase chiroselective logic gates. Org. Biomol. Chem. 9, 1717-1719.
  • A. Bonamore; I. Rovardi; F. Gasparrini; P. Baiocco; M. Barba; C. Molinaro; B. Botta; A. Boffi; A. Macone (2010). Enzymatic, stereoselective synthesis of (S)-norcoclaurine. Green Chem. 12, 1623-1627.
  • M. Speranza; I. D'Acquarica; C. Fraschetti; B. Botta; A. Tafi; L. Bellucci; G. Zappia (2010). Diastereoselective gas-phase ion/molecule reactions of ethanolamine neurotransmitter/amido[4]resorcinarene adducts. Int. J. Mass Spectrom. 291, 84-89.
  • B. Botta, P. Menendez; G. Zappia;, R. A. de Lima; R. Torge; G. Delle Monache (2009). Prenylated isoflavonoids: botanical distribution, structures, biological activities and biotechnological studies. An update (1995-2006). Curr. Med. Chem. 16, 3414-346.

  • B. Botta; C. Fraschetti; I. D'Acquarica; M. Speranza; F. R. Novara; J. Mattay; M. C. Letzel (2009). Gas-Phase Enantioselectivity of Chiral N-Linked Peptidoresorc[4]arene Isomers toward Dipeptides. J. Phys. Chem. A. 113, 14625-14629.
  • B. Botta; C. Fraschetti; F. R. Novara; A. Tafi; F. Sacco; L. Mannina; A. P. Sobolev; J. Mattay; M. C. Letzel; M. Speranza (2009). Interactions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: a dynamic, kinetic, and spectroscopic study. Org. & Biomol. Chem. 7, 1798-1806.
  • M. Speranza; F. Gasparrini; B. Botta; C. Villani; D. Subissati; C. Fraschetti; F. Subrizi (2009). Gas-phase enantioselective reactions in noncovalent ion-molecule complexes. Chirality 21, 69-86.
  • B. Botta; A. Tafi; F. Caporuscio; M. Botta; L. Nevola; I. D'Acquarica; C. Fraschetti; M. Speranza (2008). Modelling amphetamine/receptor interactions: a gas-phase study of complexes formed between amphetamine and Some chiral amido[4]resorcinarenes. Chemistry 14, 3585-95.
  • B. Botta; M. Pierini; G. Delle Monache; D. Subissati; F. Subrizi; G. Zappia (2008). Synthesis of amino and ammonium resorcin[4]arenes as potential receptors. Synthesis 13, 2110-2116.
  • B. Botta; I. D'Acquarica; G. Delle Monache; D. Subissati; G. Uccello-Barretta; M. Mastrini; S. Nazzi; M. Speranza (2007). Synthesis and host-guest studies of chiral N-linked peptidoresorc[4]arenes. J. Org. Chem. 72 9283-90.
  • B. Botta; I. D'Acquarica; L. Nevola; F. Sacco; L. V. Lopez; G. Zappia; C. Fraschetti; M. Speranza; A. Tafi; F. Caporuscio; M. C. Letzel; J. Mattay (2007). Bis(diamido)-bridged basket resorcin[4]arenes as enantioselective receptors for amino acids and amines. Eur. J. Org. Chem. 5995-6002.
  • B. Botta; G. Delle Monache; C. Fraschetti, L. Nevola; D. Subissati; M. Speranza (2007). Gaseous- versus solution-phase recognition of some aromatic amino esters by 2,8,14,20-tetrakis(L-valinamido)[4]resorcinarene. Int. J. Mass Spectrom. 267, 24-29.

  • B. Botta; I. D'Acquarica; G. Delle Monache; L. Nevola; D. Tullo; F. Ugozzoli; M. Pierini (2007). Nitrosonium (NO+) Complexes of Resorc[4]arenes: Spectral, Kinetic, and Theoretical Studies. J. Am. Chem. Soc. 129, 11202-11212.
  • G. Zappia, G. Cancelliere; E. Gacs-Baitz; G. Delle Monache; D. Misiti; L. Nevola; B. Botta (2007). Oxazolidin-2-one ring, a popular framework in synthetic organic chemistry part 2]. Applications and modifications. Curr. Org. Synthesis 4, 238-307.
  • G. Zappia; P. Menendez; G. Delle Monache; D. Misiti; L. Nevola; B. Botta (2007). The contribution of oxazolidinone frame to the biological activity of pharmaceutical drugs and natural products. Mini-Rev. Med. Chem. 7, 389-409.
  • G. Zappia; E. Gacs-Baitz; G. Delle Monache; D. Misiti; L. Nevola; B. Botta (2007). Oxazolidin-2-one ring, a popular framework in synthetic organic chemistry: part 1. The construction of the oxazolidin-2-one ring. Curr. Org. Synthesis 4, 81-135.
  • C. Sampaio de Andrade Lima; G. Zappia; G. Delle Monache; B. Botta (2006). Uncommon 5-Methoxyisoflavans from Desmodium canum. Europ. J. Org. Chem. 5445-5448.

  • I. D’Acquarica; L. Nevola; G. Delle Monache; E. Gács-Baitz; C. Massera; F. Ugozzoli; G. Zappia; B. Botta (2006). Cyano-resorc[5]arenes: Isolation, Conformation and Crystal Structure. Eur. J. Org. Chem. 3652-3660.

  • B. Botta; F. Caporuscio; I. D'Acquarica; G. Delle Monache; D. Subissati; A. Tafi; M. Botta; A. Filippi; M. Speranza (2006). Gas-phase enantioselectivity of chiral amido[4]resorcinarene receptors. Chemistry 12, 8096-105.
  • B. Botta; F. Caporuscio; D. Subissati; A. Tafi; M. Botta, A. Filippi; M. Speranza (2006). Flattened cone 2,8,14,20-tetrakis(L-valinamido)[4]resorcinarene: an enantioselective allosteric receptor in the gas phase. Angew. Chem. Int. Ed. Engl. 45, 2717-2720.
  • B. Botta; M. Cassani; I. D'Acquarica; D. Misiti; D. Subissati; G. Delle Monache (2005). Resorcarenes: Emerging class of macrocyclic receptors. Curr. Org. Chem. 9, 337-355.
  • B. Botta; M. Cassani; I. D'Acquarica; D. Subissati; G. Zappia; G. Delle Monache (2005). Resorcarenes: Hollow building blocks for the host-guest chemistry. Curr. Org. Chem. 9, 1167-1202.
  • B. Botta; G. Delle Monache; P. Menendez; A. Boffi (2005). Novel prenyltransferase enzymes as a tool for flavonoid prenylation. Trends in Pharmacol. Sciences 26, 606-608.
  • B. Botta;D. Subissati; A. Tafi; G. Delle Monache; A. Filippi; M. Speranza (2004). Cavity effects on the enantioselectivity of chiral amido[4]resorcinarene stereoisomers. Angew. Chem. Int. Ed. Engl. 43, 4767-4770.
  • A. Tafi, B. Botta; M. Botta, G. Delle Monache; A. Filippi; M. Speranza (2004). Chiral recognition by resorcin[4]arene receptors: intrinsic kinetics and dynamics. Chemistry 10, 4126-4135.
  • A. Vitali; B. Giardina; G. Delle Monache; F. Rocca; A. Silvestrini; A. Tafi; B. Botta (2004). Chalcone dimethylallyltransferase from Morus nigra cell cultures. Substrate specificity studies. FEBS Letters 557, 33-38.

Patent

  • B. Botta; A. Gulino; M. Botta; M. Mori; L. Di Marcotullio; P. Infante; F. Ghirga; S. Toscano; C. Ingallina; R. Alfonsi (2014). Multitarget hedgehog pathway inhibitors and uses thereof, PCT EP 2014063449.
  • B. Botta; A. Gulino; M. Botta; M. Mori; L. Di Marcotullio; P. Infante; F. Ghirga; S. Toscano; C. Ingallina; R. Alfonsi (2013). Multitarget hedgehog pathway inhibitors and uses thereof, RM2013A000366
  • A. Nunziata, G. Lionetti, E. Pierri, B. Botta, G. Cancelliere, I. D’acquarica, G. Delle Monache, F. Gasparrini, L. Nevola, D. Subissati, C. Villani (2007). Method of reducing the level of nitrogen oxides in a medium by absorption with resorcin[4]arenes. EP1738821, British American Tobacco Italia S.P.A.
  • A. Nunziata, G. Lionetti, E. Pierri, B. Botta, G. Cancelliere, I. D’acquarica, G. Delle Monache, F. Gasparrini, L. Nevola, D. Subissati, C. Villani, M. Cassani  (2006). Synthesis of resorcin[4]arenes and their use to adsorb nitrogen oxides from tobacco smoke. WO2006136950, British American Tobacco-Italia s.r.l.
  •  G. Delle Monache; F. Delle Monache; M. Carmignani; S. C. Bonnevaux; R. Espinal; C. De Luca; B. Botta (1991). Guanidine derivatives having hypotensive activity, composition containing them and process for obtaining them, PCT US 5059624 A
  •  G. Delle Monache; F. Delle Monache; B. Botta; S. C. Bonnevaux; R. Espinal; C. De Luca; M. Carmignani (1989). Guanidine derivatives having hypotensive activity, composition containing them and process for obtaining them, EP 330629 A2 19890830.

 

 

Pubblicazioni scientifiche

Anno: 2012
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells Journal of Medicinal Chemistry 2012 Sci_Dir
Chirality effects on the IRMPD spectra of basket resorcinarene/nucleoside complexes Chemistry - A European Journal 2012 Sci_Dir
Discovery of salermide-related sirtuin inhibitors: Binding mode studies and antiproliferative effects in cancer cells including cancer stem cells Journal of Medicinal Chemistry 2012 Sci_Dir
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 Antimicrobial Agents and Chemotherapy 2012 Sci_Dir
Production of Bioactives Compounds: The Importance of Pictet-Spengler Reaction in the XXI Century Plant Bioactives and Drug Discovery: Principles; Practice; and Perspectives 2012 Sci_Dir
Will integrase inhibitors be used as microbicides? Current HIV Research 2012 Sci_Dir
Anno: 2011
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase Bioorganic and Medicinal Chemistry Letters 2011 Sci_Dir
Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: A review International Journal of Molecular Sciences 2011 Sci_Dir
Developing Pyrrole-Derived Antimycobacterial Agents: A Rational Lead Optimization Approach ChemMedChem 2011 Sci_Dir
Enlarging the NSAIDs family: Ether; ester and acid derivatives of the 1;5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents Current Medicinal Chemistry 2011 Sci_Dir
Fyn kinase in brain diseases and cancer: The search for inhibitors Current Medicinal Chemistry 2011 Sci_Dir
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells Bioorganic and Medicinal Chemistry Letters 2011 Sci_Dir
N-linked peptidoresorc[4]arene-based receptors as noncompetitive inhibitors for α-chymotrypsin Journal of Organic Chemistry 2011 Sci_Dir
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile Bioorganic and Medicinal Chemistry 2011 Sci_Dir
Unprecedented gas-phase chiroselective logic gates Organic and Biomolecular Chemistry 2011 Sci_Dir
Anno: 2010
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
An enzymatic; stereoselective synthesis of (S)-norcoclaurine Green Chemistry 2010 Sci_Dir
Diastereoselective gas-phase ion/molecule reactions of ethanolamine neurotransmitter/amido[4]resorcinarene adducts International Journal of Mass Spectrometry 2010 Sci_Dir
Effects of air pollution on production of essential oil in Feijoa Sellowiana Berg. grown in the 'Italian triangle of death' International Journal of Environment and Health 2010 Sci_Dir
Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin Bioorganic and Medicinal Chemistry 2010 Sci_Dir
Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors ChemMedChem 2010 Sci_Dir
Norcoclaurine synthase: Mechanism of an enantioselective pictet-spengler catalyzing enzyme Molecules 2010 Sci_Dir
Novel Ester and acid derivatives of the 1;5-diarylpyrrole Scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation Journal of Medicinal Chemistry 2010 Sci_Dir
Anno: 2009
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
1;5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: Design; synthesis; and microbiological evaluation European Journal of Medicinal Chemistry 2009 Sci_Dir
A p-quinol isoflavan and two new isoflavanones from Desmodium canum Natural Product Research 2009 Sci_Dir
Gas-phase enantioselective reactions in noncovalent ion-molecule complexes Chirality 2009 Sci_Dir
Gas-Phase enantioselectivity of chiral N-Linked peptidoresorc[4]arene isomers toward dipeptides Journal of Physical Chemistry A 2009 Sci_Dir
Interactions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: A dynamic; kinetic; and spectroscopic study Organic and Biomolecular Chemistry 2009 Sci_Dir
Peroxidase-like activity of Thermobifida fusca hemoglobin: The oxidation of dibenzylbutanolide Journal of Molecular Catalysis B: Enzymatic 2009 Sci_Dir
Prenylated isoflavonoids: Botanical distribution; structures; biological activities and biotechnological studies. An update (1995-2006) Current Medicinal Chemistry 2009 Sci_Dir
Structural basis of enzymatic (S)-norcoclaurine biosynthesis Journal of Biological Chemistry 2009 Sci_Dir
Anno: 2008
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles; new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis; structure-activity relationship; and molecular modeling studies Journal of Medicinal Chemistry 2008 Sci_Dir
1;5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings Journal of Medicinal Chemistry 2008 Sci_Dir
5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones; a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure - Activity relationship profile Journal of Medicinal Chemistry 2008 Sci_Dir
Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR; homology and docking studies European Journal of Medicinal Chemistry 2008 Sci_Dir
Modelling amphetamine/receptor interactions: A gas-phase study of complexes formed between amphetamine and some chiral amido[4] resorcinarenes Chemistry - A European Journal 2008 Sci_Dir
New oxazolidinone derivatives as antibacterial agents with improved activity Expert Opinion on Therapeutic Patents 2008 Sci_Dir
Synthesis of amino and ammonium resorcin[4]arenes as potential receptors Synthesis 2008 Sci_Dir
Synthesis; biological evaluation; and enzyme docking simulations of 1;5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity Journal of Medicinal Chemistry 2008 Sci_Dir
Synthesis; cannabinoid receptor affinity; and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides Journal of Medicinal Chemistry 2008 Sci_Dir
Synthesis; in vitro; and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1;5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents Bioorganic and Medicinal Chemistry 2008 Sci_Dir
Anno: 2007
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Bis(diamido)-bridged basket resorcin[4]arenes as enantioselective receptors for amino acids and amines European Journal of Organic Chemistry 2007 Sci_Dir
Cyclooxygenase-2 inhibitors. 1;5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/ cyclooxygenase-1 selectivity Journal of Medicinal Chemistry 2007 Sci_Dir
Gaseous- versus solution-phase recognition of some aromatic amino esters by 2;8;14;20-tetrakis(L-valinamido)[4]resorcinarene International Journal of Mass Spectrometry 2007 Sci_Dir
Nitrosonium complexes of resorc[4]arenes: Spectral; kinetic; and theoretical studies Journal of the American Chemical Society 2007 Sci_Dir
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity International Journal of Biochemistry and Cell Biology 2007 Sci_Dir
Oxazolidin-2-one ring; a popular framework in synthetic organic chemistry part 2 [1]. Applications and modifications Current Organic Synthesis 2007 Sci_Dir
Oxazolidin-2-one ring; a popular framework in synthetic organic chemistry: Part 1. The construction of the oxazolidin-2-one ring Current Organic Synthesis 2007 Sci_Dir
Synthesis and host-guest studies of chiral N-linked peptidoresorc[4]arenes Journal of Organic Chemistry 2007 Sci_Dir
The contribution of oxazolidinone frame to the biological activity of pharmaceutical drugs and natural products Mini-Reviews in Medicinal Chemistry 2007 Sci_Dir
Anno: 2006
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1; a polyanionic compound endowed with anti-HIV-1 activity Journal of Chemical Information and Modeling 2006 Sci_Dir
Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity Journal of Medicinal Chemistry 2006 Sci_Dir
Cyanoresorc[5]arenes: Isolation; conformation and crystal structure European Journal of Organic Chemistry 2006 Sci_Dir
Flattened cone 2;8;14;20-tetrakis(L-valinamido)-[4]resorcinarene: An enantioselective allosteric receptor in the gas phase Angewandte Chemie - International Edition 2006 Sci_Dir
Gas-phase enantioselectivity of chiral amido[4]resorcinarene receptors Chemistry - A European Journal 2006 Sci_Dir
Purification and characterization of an antifungal thaumatin-like protein from Cassia didymobotrya cell culture Plant Physiology and Biochemistry 2006 Sci_Dir
Synthesis and biological properties of novel; uracil-containing histone deacetylase inhibitors Journal of Medicinal Chemistry 2006 Sci_Dir
Triterpenoids and ellagic acid derivatives from in vitro cultures of Camptotheca acuminata Decaisne Plant Physiology and Biochemistry 2006 Sci_Dir
Uncommon 5-methoxyisoflavans from Desmodium canum European Journal of Organic Chemistry 2006 Sci_Dir
Anno: 2005
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
1;5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors Journal of Medicinal Chemistry 2005 Sci_Dir
Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H- pyrrol-3-yl)methyl]-1H-imidazole: Synthesis; anti-Candida activity; and QSAR studies Journal of Medicinal Chemistry 2005 Sci_Dir
Novel prenyltransferase enzymes as a tool for flavonoid prenylation Trends in Pharmacological Sciences 2005 Sci_Dir
Prenylated flavonoids: Pharmacology and biotechnology Current Medicinal Chemistry 2005 Sci_Dir
Resorcarenes: Emerging class of macrocyclic receptors Current Organic Chemistry 2005 Sci_Dir
Resorcarenes: Hollow building blocks for the host-guest chemistry Current Organic Chemistry 2005 Sci_Dir
Xanthones from calli of Hypericum perforatum subsp. perforatum Natural Product Research 2005 Sci_Dir
Anno: 2004
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Cavity effects on the enantioselectivity of chiral amido[4]resorcinarene stereoisomers Angewandte Chemie - International Edition 2004 Sci_Dir
Chalcone dimethylallyltransferase from Morus nigra cell cultures. Substrate specificity studies FEBS Letters 2004 Sci_Dir
Chiral recognition by resorcin[4]arene receptors: Intrinsic kinetics and dynamics Chemistry - A European Journal 2004 Sci_Dir
Anno: 2003
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Novel hypotensive agents from Verbesina caracasana: Structure; synthesis and pharmacology Current Medicinal Chemistry 2003 Sci_Dir
Special topic issue on the theme of natural products: Preface Pure and Applied Chemistry 2003
Synthesis and molecular modelling studies of resorcin[4]arene-capped porphyrins Organic and Biomolecular Chemistry 2003 Sci_Dir
Three isoflavanones with cannabinoid-like moieties from Desmodium canum Phytochemistry 2003 Sci_Dir
Anno: 2002
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
A biphenyl; a dihydrophenanthrene and a xanthone from Clusia paralycola Heterocycles 2002
Abietane diterpenoids from callus cultures of Taxus baccata Planta Medica 2002 Sci_Dir
Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole; synthesis; anti-Candida activity; and quantitative structure-analysis relationship studies Journal of Medicinal Chemistry 2002 Sci_Dir
Effects of alkaloid precursor feeding on a Camptotheca acuminata cell line Plant Physiology and Biochemistry 2002 Sci_Dir
Enantioselective guest exchange in a chiral resorcin[4]arene cavity Journal of the American Chemical Society 2002 Sci_Dir
Lipase-catalyzed regioselective acylation of resorcin[4]arenes Journal of Molecular Catalysis - B Enzymatic 2002 Sci_Dir
Synthesis and interaction with copper(II) cations of cyano- and aminoresorcin[4]arenes Journal of Organic Chemistry 2002 Sci_Dir
Anno: 2001
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Aryltetralin ligrans: Chemistry; pharmacology and biotransformations Current Medicinal Chemistry 2001
Novel hypotensive agents from Verbesina caracasana. 8. Synthesis and pharmacology of (3;4-dimethoxycinnamoyl)-N1-agmatine and synthetic analogues Journal of Medicinal Chemistry 2001 Sci_Dir
Synthesis and biosynthesis of isocordoin Planta Medica 2001 Sci_Dir
Anno: 2000
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Building a pharmacophore model for a novel class of antitubercular compounds Farmaco 2000 Sci_Dir
Chiral azole derivatives. 4.1 Enantiomers of bifonazole and related antifungal agents: Synthesis; configuration assignment; and biological evaluation Journal of Organic Chemistry 2000 Sci_Dir
Design and realization of a tailor-made enzyme to modify the molecular recognition of 2-arylpropionic esters by Candida rugosa lipase Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology 2000 Sci_Dir
Stereoselective synthesis of α-aryl-2-benzofuranmethanamines and α- aryl-1H-indole-2-methanamines through palladium-mediated annulation of chiral α-arylpropargylamines Tetrahedron Asymmetry 2000 Sci_Dir
Synthesis and preliminary biological evaluation of 4;6-disubstituted 3-cyanopyridin-2(1H)-ones; a new class of calcium entry blockers Bioorganic and Medicinal Chemistry Letters 2000 Sci_Dir
Synthesis of C-alkylcalix[4]arenes; 6. - The interaction of resorcin[4]arenes with Fe(III) in chloroform European Journal of Organic Chemistry 2000
Anno: 1999
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Further hypotensive metabolites from Verbesina caracasana. Bioorganic and Medicinal Chemistry Letters 1999 Sci_Dir
Novel hypotensive agents from Verbesina caracasana. 6. Synthesis and pharmacology of caracasandiamide Journal of Medicinal Chemistry 1999 Sci_Dir
Peroxidase from cell cultures of cassia didymobotrya: A review and comparison with horseradish peroxidase Heterocycles 1999
β-Glucosyltransferase in cell cultures of Verbesina caracasana Heterocycles 1999
Anno: 1998
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Glycated human hemoglobin (HbA(1c)): Functional characteristics and molecular modeling studies Biophysical Chemistry 1998 Sci_Dir
Purification and partial characterization of a peroxidase from plant cell cultures of Cassia didymobotrya and biotransformation studies Biochemical Journal 1998 Sci_Dir
Rational synthesis of resorcarenes with alternating substituents at their bridging methine carbons Journal of Organic Chemistry 1998 Sci_Dir
Anno: 1997
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A new fungal growth inhibitor from Trichoderma viride Tetrahedron 1997 Sci_Dir
Synthesis of C-Alkylcalix[4] arenes. 4. Design; Synthesis; and Computational Studies of Novel Chiral Amido[4]resorcinarenes Journal of Organic Chemistry 1997
Synthesis of C-Alkylcalix[4]arenes. 5. Design; Synthesis; Computational Studies; and Homodimerization of Polymethylene-Bridged Resorc[4]arenes Journal of Organic Chemistry 1997
The cellular distribution of antifeedant prenylated anthranoids in the tissues of Vismia guianensis during development Protoplasma 1997
Anno: 1996
Titolo pubblicazione Rivista Anno link Scopus link Sci_Dir
Antimicrobial isoflavanones from Desmodium Canum Phytochemistry 1996 Sci_Dir

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