D’ACQUARICA Ilaria

Associate Professor
Settore Scientifico-Disciplinare: 
CHIM/06 (Chimica Organica)
Settore concorsuale: 
03/C1
Informazioni personali
Curriculum vitae (en): 

EDUCATION & ACADEMIC EMPLOYMENT 

1993: Master Degree in “Medicinal Chemistry”, achieved with full marks (“magna cum laude”) at the University “La Sapienza” of Rome defending a thesis entitled: “Novel chiral stationary phases containing L- and D-phenylalaninamide for the ligand-exchange chromatography of amino acids derivatives”, supervisor Prof. Francesco Gasparrini.

1998: Ph.D. Degree in “Pharmaceutical Sciences” obtained at the University “La Sapienza” of Rome (Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive) defending a Ph.D. thesis entitled “Synthesis and evaluation of new chiral stationary phases for the direct resolution of racemates by HPLC”, supervisor Prof. Francesco Gasparrini (from 1994 to 1997).

1999: awarded the Farmindustria Prize “New researchers generation” by the Italian Chemical Society

1999-2004 Temporary fellowship at the University “La Sapienza” of Rome (Organic Chemistry).

2004-2015 Assistant professor of organic chemistry at the University “La Sapienza” of Rome.

 

CURRENT POSITION

Since 2015, she is associate professor of organic chemistry at the Sapienza University of Rome (Dipartimento di Chimica e Tecnologie del Farmaco).

Since 2018, she received the Italian National Scientific Qualification (Abilitazione Scientifica Nazionale, ASN) as full professor of organic chemistry.

 

PUBLICATIONS 

Ilaria D'Acquarica is author of 76 papers published in international journals, 6 book chapters and 2 patents, and has presented her results in many national and international meetings.

The H-index for her scientific production is 26 (Source: Scopus, collection period: December 2021).

 

REVIEWER ACTIVITY

Since 2001, she is serving as a referee mainly for the Journal of Chromatography A and B (Elsevier, The Netherlands), Journal of Pharmaceutical and Biomedical Analysis (Elsevier, The Netherlands) and a variety of both analytical and pharmaceutical journals.

In 2006, she was awarded the Top Referee 2006 certificate by the Journal of Chromatography A, and in 2016 the Top Referee 2016 certificate by the Jounal of Pharmaceutical and Biomedical Analysis.

Reviewer activity on Publons website

Didattica
Ricerca
Finanziamenti: 
  • Progetto Giovani Ricercatori (MURST) Anno 2000. Titolo: “Strategie sintetiche innovative per la preparazione di nuove fasi stazionarie chirali e loro applicazioni in campo farmaceutico”.
  • Progetto Giovani Ricercatori (MURST) Anno 2002. Titolo: “Sviluppo ed applicazioni di nuove tecniche cromatografiche enantioselettive accoppiate alla spettrometria di massa nel monitoraggio biologico di farmaci chirali”.
  • Progetto di Ricerca Universitario (MIUR) Anno 2009. Titolo: “HPLC capillare basata su monoliti organici nello screening di nuovi potenziali inibitori dell'enzima istone deacetilasi (HDAC)”.
  • Contratto di Ricerca tra Imperial Europe s.r.l. (start-up innovativa ai sensi del D.L. 179/12) e Dipartimento di Chimica e Tecnologie del Farmaco (Anno 2012) sul tema “Preparazione e valutazione di carrier per la realizzazione di repellenti a base di oli essenziali”.
  • Accordo Interuniversitario Internazionale (Anno 2016) tra la Sapienza Università di Roma (Italia) e l'Universidade Federal de Santa Catarina (Prof. Hernan Terenzi, Florianopolis, Brasile) avente come scopo l’isolamento e la caratterizzazione di prodotti naturali con attività antitubercolare.
Aree di interesse: 
  1. Separation chemistry; HPLC analysis of complex biological samples; synthesis, characterization and evaluation of conventional (achiral) and novel (chiral) stationary phases for HPLC, UHPLC and HRGC applications; resolutions of chiral compounds (drugs, food, biologically active substances, metabolites in biological fluids).

  2. Biotransformations of organic substrates by enzymatic preparations.

  3. Enantioselective molecular recognition in the gas phase by resorc[4]arenes receptors.

  4. Purification and characterization of naturally occurring small molecules with anticancer activity (inhibition of the Hedgehog signaling pathway).

Pubblicazioni scientifiche

Anno: 2020

  1. Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19
    Pubblicato su: Drug Discovery Today
    - Vedi su: 'ScienceDirect'

Anno: 2018

  1. Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds
    Pubblicato su: Journal of Pharmaceutical and Biomedical Analysis
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. A promising natural product; pristimerin; results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
    Pubblicato su: Pharmacological Research
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
    Pubblicato su: Journal of Enzyme Inhibition and Medicinal Chemistry
    - Vedi su: 'ScienceDirect'
  5. Synthesis of Bromoundecyl Resorc[4]arenes and Applications of the Cone Stereoisomer as Selector for Liquid Chromatography
    Pubblicato su: The Journal of Organic Chemistry
    - Vedi su: 'ScienceDirect'

Anno: 2017

  1. Green routes for the production of enantiopure benzylisoquinoline alkaloids
    Pubblicato su: International Journal of Molecular Sciences
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2016

  1. Resorc[4]arenes as preorganized synthons for surface recognition and host-guest chemistry
    Pubblicato su: Calixarenes and Beyond
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2011

  1. Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry
    Pubblicato su: Journal of Chromatography A
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'

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