MAI Antonello

Full Professor
Settore Scientifico-Disciplinare: 
CHIM/08
Informazioni personali
Curriculum vitae (it): 
Curriculum vitae (en): 
Didattica
Ricerca

Pubblicazioni scientifiche

Anno: 2021

  1. The two-faced role of sirt6 in cancer
    Pubblicato su: Cancers
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer
    Pubblicato su: Cancers
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress
    Pubblicato su: Frontiers in Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes
    Pubblicato su: Cells
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  5. Emerging Therapeutic Potential of SIRT6 Modulators
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2020

  1. Preface
    Pubblicato su: Topics in Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Properly substituted cyclic bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 inhibitors and induced apoptosis in cancer cells
    Pubblicato su: Molecules
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  3. Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells
    Pubblicato su: ACS Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  5. Detrimental effects of the ‘bath salt’ methylenedioxypyrovalerone on social play behavior in male rats
    Pubblicato su: Neuropsychopharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  6. Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer
    Pubblicato su: Frontiers in Oncology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  7. Diphenylene Iodonium Is a Noncovalent MAO Inhibitor: A Biochemical and Structural Analysis
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  8. Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
    Pubblicato su: Expert Opinion on Therapeutic Patents
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  9. Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization
    Pubblicato su: ACS Chemical Biology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  10. Targeting histone acetylation/deacetylation in parasites: an update (2017–2020)
    Pubblicato su: Current Opinion in Chemical Biology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  11. A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action
    Pubblicato su: Redox Biology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  12. Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation
    Pubblicato su: Science Advances
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  13. Downregulation of miR-326 and its host gene β-arrestin1 induces pro-survival activity of E2F1 and promotes medulloblastoma growth
    Pubblicato su: Molecular Oncology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  14. Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene
    Pubblicato su: Human Genetics
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  15. The Innovative Potential of Statins in Cancer: New Targets for New Therapies
    Pubblicato su: Frontiers in Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  16. CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas
    Pubblicato su: Frontiers in Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  17. The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line
    Pubblicato su: Frontiers in Oncology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  18. Epigenetic polypharmacology: A new frontier for epi-drug discovery
    Pubblicato su: Medicinal Research Reviews
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  19. Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  20. From PARP1 to TNKS2 inhibition: A structure-based approach
    Pubblicato su: ACS Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  21. Identification of inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes
    Pubblicato su: International Journal of Molecular Sciences
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  22. Inhibition of class I HDACs imprints adipogenesis toward oxidative and brown-like phenotype
    Pubblicato su: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  23. Lysine Acetyltransferase Inhibitors From Natural Sources
    Pubblicato su: Frontiers in Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  24. Novel Pyridine-Based Hydroxamates and 2′-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  25. Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation
    Pubblicato su: Cancers
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2019

  1. Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat
    Pubblicato su: Journal of Psychopharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  2. Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats
    Pubblicato su: Frontiers in Molecular Neuroscience
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  4. Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
    Pubblicato su: Clinical Epigenetics
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'

Anno: 2018

  1. Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers
    Pubblicato su:
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  2. A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy
    Pubblicato su: Molecular Cancer Therapeutics
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  3. Application of small epigenetic modulators in pediatric medulloblastoma
    Pubblicato su: Frontiers in Pediatrics
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Effects of Class II-Selective Histone Deacetylase Inhibitor on Neuromuscular Function and Disease Progression in SOD1-ALS Mice
    Pubblicato su: Neuroscience
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  5. Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells
    Pubblicato su: Philosophical Transactions of the Royal Society B: Biological Sciences
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  6. Trends of LSD1 inhibitors in viral infections
    Pubblicato su: Future Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  7. Six Years (2012–2018) of Researches on Catalytic EZH2 Inhibitors: The Boom of the 2-Pyridone Compounds
    Pubblicato su: Chemical Record
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  8. HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
    Pubblicato su: Scientific Reports
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'

Anno: 2017

  1. Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice
    Pubblicato su: Neuroscience Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity
    Pubblicato su: Bioorganic and Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
    Pubblicato su: Oncotarget
    - Vedi su: 'Scopus'
  4. Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
    Pubblicato su: Clinical Epigenetics
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  6. EZH2 inhibitors: a patent review (2014-2016)
    Pubblicato su: Expert Opinion on Therapeutic Patents
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  7. Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity
    Pubblicato su: Journal of Enzyme Inhibition and Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2016

  1. Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model
    Pubblicato su: Autoimmunity
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. DNA methyltransferases inhibitors from natural sources
    Pubblicato su: Current Topics in Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. LSD1 inhibitors: A patent review (2010-2015)
    Pubblicato su: Expert Opinion on Therapeutic Patents
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation
    Pubblicato su: Future Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. 1;4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2015

  1. Emerging approaches for histone deacetylase inhibitor drug discovery
    Pubblicato su: Expert Opinion on Drug Discovery
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Novel histone deacetylase inhibitors induce growth arrest; apoptosis; and differentiation in sarcoma cancer stem cells
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2014

  1. Novel inhibitors of human histone deacetylases: Design; synthesis and bioactivity of 3-alkenoylcoumarines
    Pubblicato su: Bioorganic and Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells
    Pubblicato su: Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2013

  1. Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity
    Pubblicato su: European Journal of Organic Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells
    Pubblicato su: MedChemComm
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

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