SILVESTRI Romano

Full Professor
Settore Scientifico-Disciplinare: 
CHIM/08
Informazioni personali
Curriculum vitae (it): 
Curriculum vitae (en): 
Didattica
Aree di afferenza: 
- Area Farmaceutica
- Corso di Laurea in Farmacia
- Corso di Laurea in Scienze Farmaceutiche Applicate
- Scuola di Specializzazione in Farmacia Ospedaliera
Ricerca

Pubblicazioni scientifiche

Anno: 2021

  1. Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway
    Pubblicato su: European Journal of Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  3. CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme
    Pubblicato su: European Journal of Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'

Anno: 2020

  1. Sulfonamide Inhibitors of β-Catenin Signaling as Anticancer Agents with Different Output on c-MYC
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage
    Pubblicato su: ACS Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors
    Pubblicato su: ACS Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
    Pubblicato su: Arabian Journal of Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Design, Synthesis and Discovery of N,N’-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication
    Pubblicato su: ChemMedChem
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  6. HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: Focus on EBP50 and IRSp53
    Pubblicato su: Neuro-Oncology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  7. Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
    Pubblicato su: Journal of Computer-Aided Molecular Design
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  8. Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites
    Pubblicato su: Scientific Reports
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  9. New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  10. Targeting the Interaction between the SH3 Domain of Grb2 and Gab2
    Pubblicato su: Cells
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2019

  1. Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  2. Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents
    Pubblicato su: ACS Medicinal Chemistry Letters
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  3. Towards modern anticancer agents that interact with tubulin
    Pubblicato su: European Journal of Pharmaceutical Sciences
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B
    Pubblicato su: Molecules
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  5. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
    Pubblicato su: European Journal of Medicinal Chemistry
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'

Anno: 2018

  1. Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects
    Pubblicato su: British Journal of Clinical Pharmacology
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  2. A high-throughput screening of a chemical compound library in ovarian cancer stem cells
    Pubblicato su: Combinatorial Chemistry and High Throughput Screening
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'
  3. Arginine- and lysine-rich peptides: Synthesis, characterization and antimicrobial activity
    Pubblicato su: Letters in Drug Design and Discovery
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
  4. Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors
    Pubblicato su: Antiviral Chemistry and Chemotherapy
    - Vedi su: 'Scopus'
    - Vedi su: 'ScienceDirect'
    - Vedi su: 'PubMed'

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