Publications 2019-2021
1. Felipe R.P. Mansoldo, Emanuela Berrino, Paolo Guglielmi, Simone Carradori, Fabrizio Carta, Daniela Secci, Claudiu T. Supuran, Alane B. Vermelho. An innovative spectroscopic approach for qualitative and quantitative evaluation of Mb-CO from myoglobin carbonylation reaction through chemometrics methods. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 267 (2022) 120602
2. Sisto, F., Carradori, S., Guglielmi, P., Spano, M., Secci, D., Granese, A., Sobolev, A.P., Grande, R., Campestre, C., Di Marcantonio, M.C., Mincione, G. Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line Molecules (2021) 26 (7).
3. Gallorini, M.; Berardi, A.C.; Ricci, A.; Passeri, C.A.L.; Zara, S.; Oliva, F.; Cataldi, A.; Carta, F.; Supuran C.T.; Guglielmi, P.; Carradori, S. Dual acting carbon monoxide releasing molecules and carbonic anhydrase inhibitors differentially modulate inflammation in human tenocytes. Biomedicines 2021, 9, 1–18, doi:10.3390/biomedicines9020141.
4. D'Ascenzio, M., Secci, D., Carradori, S., Zara, S., Guglielmi, P., Cirilli, R., Pierini, M., Poli, G., Tuccinardi, T., Angeli, A., Supuran, C.T., 1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors J. Med. Chem. (2020) 63 (5), pp. 2470-2488.
5. Carradori, S., Secci, D., Guglielmi, P., Pierini, M., Cirilli, R. High-performance liquid chromatography enantioseparation of chiral 2-(benzylsulfinyl) benzamide derivatives on cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase (2020) Journal of Chromatography A, 1610, art. no. 460572.
6. Guglielmi, P., Mathew, B., Secci, D., Carradori, S. Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors European Journal of Medicinal Chemistry (2020) 205, art. no. 112650.
7. Maccelli, A., Cesa, S., Cairone, F., Secci, D., Menghini, L., Chiavarino, B., Fornarini, S., Crestoni, M.E., Locatelli, M. Metabolic profiling of different wild and cultivated Allium species based on high-resolution mass spectrometry, high-performance liquid chromatography-photodiode array detector, and color analysis Journal of Mass Spectrometry (2020) 55 (11), art. no. e4525.
8. Sisto, F., Carradori, S., Guglielmi, P., Traversi, C.B., Spano, M., Sobolev, A.P., Secci, D., Di Marcantonio, M.C., Haloci, E., Grande, R., Mincione, G.Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of H. Pylori strains and ags cell proliferation Pharmaceuticals (2020) 13 (11), art. no. 405, pp. 1-21.
9. Luisi, G., Carradori, S., Grande, R., Secci, D., Guglielmi, P. Antimalarial agents from medicinal plant and fungal sources Plant-derived Bioactives: Production, Properties and Therapeutic Applications (2020) pp. 297-334.
10. Guglielmi, P., Rotondi, G., Secci, D., Angeli, A., Chimenti, P., Nocentini, A., Bonardi, A., Gratteri, P., Carradori, S., Supuran, C.T. Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation Journal of Enzyme Inhibition and Medicinal Chemistry (2020) 35 (1), pp. 1891-1905.
11. Veschi, S., Carradori, S., De Lellis, L., Florio, R., Brocco, D., Secci, D., Guglielmi, P., Spano, M., Sobolev, A.P., Cama, A. Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents Journal of Enzyme Inhibition and Medicinal Chemistry (2020) 35 (1), pp. 1331-1344.
12. Martile, M.D., Gabellini, C., Desideri, M., Matraxia, M., Farini, V., Valentini, E., Carradori, S., Ercolani, C., Buglioni, S., Secci, D., Andreazzoli, M., Bufalo, D.D., Trisciuoglio, D. Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells Journal of Experimental and Clinical Cancer Research (2020) 39 (1), art. no. 103.
13. Guglielmi, P.; Pontecorvi, V.; Rotondi, G. Natural compounds and extracts as novel antimicrobial agents. Expert Opin. Ther. Pat. 2020, 30, 949–962.
14. Mathew, B.; Carradori, S.; Guglielmi, P.; Uddin, M.S.; Kim, H. New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door. Curr. Med. Chem. 2020, 28, 266–283, doi:10.2174/0929867327666200121165931.
15. Guglielmi, P., Carradori, S., Ammazzalorso, A., Secci, D. Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement? (2019) Expert Opinion on Drug Discovery, 14 (10), pp. 995-1035.
16. Guglielmi, P., Carradori, S., Poli, G., Secci, D., Cirilli, R., Rotondi, G., Chimenti, P., Petzer, A., Petzer, J.P. Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5- diphenyl-4,5-dihydro-(1h)-pyrazoles (2019) Molecules, 24 (3), art. no. 484.
17. Marconi, G.D.; Carradori, S.; Ricci, A.; Guglielmi, P.; Cataldi, A.; Zara, S. Kinesin Eg5 targeting inhibitors as a new strategy for gastric adenocarcinoma treatment. Molecules 2019, 24, doi:10.3390/molecules24213948.
18. Secci, D., Locatelli, M., Kabir, A., Salvatorelli, E., Macedonio, G., Mollica, A., Carradori, S. Investigation on the stability of new biologically active thiosemicarbazone- derived compounds by a validated HPLC-PDA method (2019) Current Analytical Chemistry, 15 (3), pp. 313-320.
19. Secci, D., Carradori, S., Petzer, A., Guglielmi, P., D’Ascenzio, M., Chimenti, P., Bagetta, D., Alcaro, S., Zengin, G., Petzer, J.P., Ortuso, F. 4-(3-Nitrophenyl) thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis (2019) Journal of Enzyme Inhibition and Medicinal Chemistry, 34 (1), pp. 597-612.
20. Rotondi, G., Guglielmi, P., Carradori, S., Secci, D., De Monte, C., De Filippis, B., Maccallini, C., Amoroso, R., Cirilli, R., Akdemir, A., Angeli, A., Supuran, C.T. Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl) benzoic acid scaffold (2019) Journal of Enzyme Inhibition and Medicinal Chemistry, 34 (1), pp. 1400-1413.
21. Guglielmi, P., Secci, D., Petzer, A., Bagetta, D., Chimenti, P., Rotondi, G., Ferrante, C., Recinella, L., Leone, S., Alcaro, S., Zengin, G., Petzer, J.P., Ortuso, F., Carradori, S. Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity (2019) Journal of Enzyme Inhibition and Medicinal Chemistry, 34 (1), pp. 1511-1525.
22. Marconi, G.D.; Gallorini, M.; Carradori, S.; Guglielmi, P.; Cataldi, A.; Zara, S. The up-regulation of oxidative stress as a potential mechanism of novel MAO-B inhibitors for glioblastoma treatment. Molecules 2019, 24, doi:10.3390/molecules24102005.
23. Guglielmi, P.; Carradori, S.; Campestre, C.; Poce, G. Novel therapies for glaucoma: a patent review (2013-2019). Expert Opin. Ther. Pat. 2019, 29, 769–780, doi:10.1080/13543776.2019.1653279
Publications 2015-2018
1. Carradori, S., Secci, D., Petzer, J.P.. MAO inhibitors and their wider applications: a patent review, (2018), Expert Opinion on Therapeutic Patents, 28, 3, pp 211-226.
2. Bellusci, M., Guglielmi, P., Masi, A., Padella, F., Singh, G., Yaacoub, N., Peddis, D., Secci, D.. Magnetic Metal-Organic Framework Composite by Fast and Facile Mechanochemical Process, (2018), Inorganic Chemistry, 57, 4, pp. 1806-1814.
3. Mocan, A., Carradori, S., Locatelli, M., Secci, D., Cesa, S., Mollica, A., Riga, S., Angeli, A., Supuran, C.T., Celia, C., Di Marzio, L., Bioactive isoflavones from Pueraria lobata root and starch: Different extraction techniques and carbonic anhydrase inhibition, (2018), Food and Chemical Toxicology, 112, pp.441-447.
4. Menghini, L., Bellagamba, G., Marcelli, F., De Luca E., Armellani, L., Cifelli, R., Granese, A., Kucukerkan, N., Z., Aktumsek, A., Zengin, G. Analytical Procedures for Secondary Metabolites Determination: Recent Trends and Future Perspectives, (2018), Letters in Drug Design and Discovery, 15(3): pp.281 - 293
5. Carradori, S., Secci, D., Faggi, C., Cirilli, R., A chromatographic study on the exceptional chiral recognition of 2-(benzylsulfinyl)benzamide by an immobilized-type chiral stationary phase based on cellulose tris(3,5-dichlorophenylcarbamate), (2018), Journal of Chromatography A, 1531, pp.151-156.
6. Carradori, S., Ortuso, F., Petzer, A., Bagetta, D., De Monte, C., Secci, D., De Vita, D., Guglielmi, P., Zengin, G., Aktumsek, A., Alcaro, S., Petzer, J.P., Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents, (2018), European Journal of Medicinal Chemistry, 143, pp. 1543-1552.
7. D'Ascenzio, M., Guglielmi, P., Carradori, S., Secci, D., Florio, R., Mollica, A., Ceruso, M., Akdemir, A., Sobolev, A.P., Supuran, C.T. Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms (2017) Journal of enzyme inhibition and medicinal chemistry, 32 (1), pp. 51-59.
8. Nescatelli, R., Carradori, S., Marini, F., Caponigro, V., Bucci, R., De Monte, C., Mollica, A., Mannina, L.,Ceruso, M., Supuran, C.T., Secci,D. Geographical characterization by MAE-HPLC and NIR methodologies and carbonic anhydrase inhibition of Saffron components (2017) Food Chemistry, 221, pp. 855-863.
9. Carradori, S., Bizzarri, B., D'Ascenzio, M., De Monte, C., Grande, R., Rivanera, D., Zicari, A., Mari, E., Sabatino, M., Patsilinakos, A., Ragno, R., Secci, D. Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity (2017) European Journal of Medicinal Chemistry, 140, pp. 274-292.
10. Ferrante, C., Recinella, L., Locatelli, M., Guglielmi, P., Secci, D., Leporini, L., Chiavaroli, A., Leone, S., Martinotti, S., Brunetti, L., Vacca, M., Menghini, L., Orlando, G.Protective Effects Induced by Microwave-Assisted Aqueous Harpagophytum Extract on Rat Cortex Synaptosomes Challenged with Amyloid β-Peptide (2017) Phytotherapy Research, 31 (8), pp. 1257-1264
11. Locatelli, M., Ferrante, C., Carradori, S., Secci, D., Leporini, L., Chiavaroli, A., Leone, S., Recinella, L., Orlando, G., Martinotti, S., Brunetti, L., Vacca, M., Menghini, L.Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model (2017) Phytotherapy Research, 31 (6), pp. 937-944.
12. Pierini, M., Carradori, S., Menta, S., Secci, D., Cirilli, R. 3-(Phenyl-4-oxy)-5-phenyl-4,5-dihydro-(1H)-pyrazole: A fascinating molecular framework to study the enantioseparation ability of the amylose (3,5-dimethyl phenylcarbamate) chiral stationary phase. Part II. Solvophobic effects in enantiorecognition process (2017) Journal of Chromatography A, 1499, pp. 140-148.
13. Carradori, S., Secci, D., Bizzarri, B., Chimenti, P., De Monte, C., Guglielmi, P., Campestre, C., Rivanera, D., Bordón, C., Jones-Brando, L. Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives (2017) Journal of Enzyme Inhibition and Medicinal Chemistry, 32 (1), pp. 746-758.
14. Rinaldi, F., Hanieh, P.N., Longhi, C., Carradori, S., Secci, D., Zengin, G., Ammendolia, M.G., Mattia, E., Del Favero, E., Marianecci, C., Carafa, M. Neem oil nanoemulsions: characterisation and antioxidant activity (2017) Journal of Enzyme Inhibition and Medicinal Chemistry, 32 (1), pp. 1265-1273.
15. Gidaro, M.C., Alcaro, S.,Secci, D., Rivanera, D., Mollica, A., Agamennone, M., Giampietro, L., Carradori, S. Identification of new anti-Candida compounds by ligand-based pharmacophore virtual screening (2016) Journal of Enzyme Inhibition and Medicinal Chemistry, 31 (6), pp. 1703-1706.
16. D’Ascenzio, M., Guglielmi, P., Carradori, S., Secci, D., Florio, R., Mollica, A., Ceruso, M., Akdemir, A., Sobolev, A.P., Supuran, C.T. Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms (2016) Journal of Enzyme Inhibition and Medicinal Chemistry, pp. 1-9.
17. Carradori, S., Pierini, M., Menta, S., Secci, D., Fioravanti, R., Cirilli, R. 3-(Phenyl-4-oxy)-5-phenyl-4,5-dihydro-(1H)-pyrazole: A fascinating molecular framework to study the enantioseparation ability of the amylose (3,5-dimethylphenylcarbamate) chiral stationary phase. Part I. Structure-enantioselectivity relationships (2016) Journal of Chromatography A, 1467, pp. 221-227.
18. Secci, D., Carradori, S., Bizzarri, B., Chimenti, P., De Monte, C., Mollica, A., Rivanera, D., Zicari, A., Mari, E., Zengin, G., Aktumsek, A. Novel 1,3-thiazolidin-4-one derivatives as promising anti- Candida agents endowed with anti-oxidant and chelating properties (2016) European Journal of Medicinal Chemistry, 117, pp. 144-156.
19. Carradori, S., Secci, D., De Monte, C., Mollica, A., Ceruso, M., Akdemir, A., Sobolev, A.P., Codispoti, R., De Cosmi, F., Guglielmi, P., Supuran, C.T. A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms (2016) Bioorganic and Medicinal Chemistry, 24 (5), pp. 1095-1105.
20 .Menta, S., Carradori, S., Siani, G., Secci, D., Mannina, L., Sobolev, A.P., Cirilli, R., Pierini, M. Elucidation of the mechanisms governing the thermal diastereomerization of bioactive chiral 1,3,4-thiadiazoline spiro-cyclohexyl derivatives towards their anancomeric stereoisomers (2016) RSC Advances, 6 (75), pp. 71262-71272.
21. De Monte, C., Carradori, S., Bizzarri, B., Bolasco, A., Caprara, F., Mollica, A., Rivanera, D., Mari, E., Zicari, A., Akdemir, A., Secci, D. Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives (2016) European Journal of Medicinal Chemistry, 107, pp. 82-96.
22. Carradori, S., Gidaro,M. C., Petzer, A., Costa,P., Chimenti,P., Alcaro, S.,Petzer,J.P. Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids (2016), J. Agric. Food Chem., 64 (47), pp. 9004–9011
23. Carradori, S., Chimenti, P., Fazzari, M., Granese, A., Angiolella, L.Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp (2016), J Enzyme Inhib Med Chem.31 (sup2): pp189-193.
24. Di Martile, M., Desideri, M., De Luca, T., Gabellini, C., Buglioni, S., Eramo, A., Sette, G., Milella, M., Rotili, D., Mai, A., Carradori, S., Secci, D., De Maria, R., Del Bufalo, D., Trisciuoglio, D. Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells (2016) Oncotarget, 7 (10), pp. 11332-11348.
25. Menta, S., Carradori, S., Secci, D., Faggi, C., Mannina, L., Cirilli, R., Pierini, M. The Anancomeric Character of the Pharmacophore 1,3,4-Thiadiazoline Framework in Chiral Spiro-Cyclohexyl Derivatives: Effects on Stereochemistry and Spiro-Junction Lability. Thermodynamic Aspects (2015) Journal of Organic Chemistry, 80 (24), pp. 11932-11940.
26. Carradori, S., Mollica, A., Ceruso, M., D’ascenzio, M., De Monte, C., Chimenti, P., Sabia, R., Akdemir, A., Supuran C. T. New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies (2015), Bioorg. Med. Chem., 23, pp. 2975-2981.
27 .De Monte, C., Carradori, S., Secci, D., D'Ascenzio, M., Guglielmi, P., Mollica, A., Morrone, S., Scarpa, S., Aglianò, A.M., Giantulli, S., Silvestri, I. Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma (2015) European Journal of Medicinal Chemistry, 105, pp. 245-262.
28. D’ascenzio, M., Chimenti, P., Gidaro, M. C., De Monte, C., De Vita, D., Granese, A., Scipione, L., Di Santo, R., Costa, G., Alcaro, S., Yáñez, M., Carradori S. (Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies (2015), J. Enzyme Inhib. Med. Chem., 30, pp.908-919.
29. De Monte, C., Bizzarri, B., Gidaro, M. C., Carradori, S., Mollica, A., Luisi, G., Granese, A.,Alcaro, S., Costa, G., Basilico, N. Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti Helicobacter pylori, anti-malarial and anti-leishmanial agents. (2015), Journal of Enzyme Inhibition and Medicinal Chemistry, 30(6), pp.1027-1033
30. D'Ambrosio, K., Carradori, S., Monti, S.M., Buonanno, M., Secci, D., Vullo, D., Supuran, C.T., De Simone, G. Out of the active site binding pocket for carbonic anhydrase inhibitors (2015) Chemical Communications, 51 (2), pp. 302-305.
31. Carradori, S., Mollica, A., De Monte, C., Granese, A., Supuran, C. T. Nitric oxide donors and selective carbonic anhydrase inhibitors: a dual pharmacological approach for the treatment of glaucoma, cancer and osteoporosis (2015) Molecules, 20, pp.5667-5679.
32. Carradori, S., Mannina, L., De Cosmi, F., Beccarini, T., Secci, D., Sobolev, A.P.
Optimization of the microwave-assisted extraction of azadirachta indica (Neem) leaves using NMR-based metabolic fingerprinting (2015) Current Bioactive Compounds, 11 (3), pp. 142-145.
