Publication (2019-2021)
1. Nardella, C., Visconti, L., Malagrinò, F., Pagano, L., Bufano, M., Nalli, M., Coluccia, A., La Regina, G., Silvestri, R., Gianni, S., Toto, A.
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
(2021) 16 (1), art. no. 15, .
2. Puxeddu, M., Shen, H., Bai, R., Coluccia, A., Bufano, M., Nalli, M., Sebastiani, J., Brancaccio, D., Da Pozzo, E., Tremolanti, C., Martini, C., Orlando, V., Biagioni, S., Sinicropi, M.S., Ceramella, J., Iacopetta, D., Coluccia, A.M.L., Hamel, E., Liu, T., Silvestri, R., La Regina, G.
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
(2021) 221, art. no. 113532, .
3. Van Dycke, J., Puxeddu, M., La Regina, G., Mastrangelo, E., Tarantino, D., Rymenants, J., Sebastiani, J., Nalli, M., Matthijnssens, J., Neyts, J., Silvestri, R., Rocha-Pereira, J.
Discovery of a novel class of norovirus inhibitors with high barrier of resistance
(2021) 14 (10), art. no. 1006, .
4. Li, S., Xu, A., Li, Y., Tan, C., La Regina, G., Silvestri, R., Wang, H., Qi, W.
RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway
(2021) 903, art. no. 174135, .
5. Daniele, S., La Pietra, V., Piccarducci, R., Pietrobono, D., Cavallini, C., D'Amore, V.M., Cerofolini, L., Giuntini, S., Russomanno, P., Puxeddu, M., Nalli, M., Pedrini, M., Fragai, M., Luchinat, C., Novellino, E., Taliani, S., La Regina, G., Silvestri, R., Martini, C., Marinelli, L.
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme
(2021) 897, art. no. 173936, .
6. Liu, T., Wu, J., Han, C., Gong, Z., Regina, G.L., Chen, J., Dou, F., Silvestri, R., Chen, C., Yu, Z.
Rs-5645 attenuates inflammatory cytokine storm induced by sars-cov-2 spike protein and lps by modulating pulmonary microbiota
(2021) 17 (13), pp. 3305-3319.
7. Nalli, M., Armijos Rivera, J.I., Masci, D., Coluccia, A., Badia, R., Riveira-Muñoz, E., Brambilla, A., Cinquina, E., Turriziani, O., Falasca, F., Catalano, M., Limatola, C., Esté, J.A., Maga, G., Silvestri, R., Crespan, E., La Regina, G.
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
(2020) 208, art. no. 112696, .
8. Di Magno, L., Di Pastena, F., Puxeddu, M., La Regina, G., Coluccia, A., Ciogli, A., Manetto, S., Maroder, M., Canettieri, G., Silvestri, R., Nalli, M.
Sulfonamide Inhibitors of β-Catenin Signaling as Anticancer Agents with Different Output on c-MYC
(2020) 15 (23), pp. 2264-2268.
9. Scala, R., Di Matteo, A., Coluccia, A., Lo Sciuto, A., Federici, L., Travaglini-Allocatelli, C., Visca, P., Silvestri, R., Imperi, F.
Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites
(2020) 10 (1), art. no. 11276, .
10. Malagrinò, F., Coluccia, A., Bufano, M., Regina, G., Puxeddu, M., Toto, A., Visconti, L., Paone, A., Magnifico, M.C., Troilo, F., Cutruzzolà, F., Silvestri, R., Gianni, S.
Targeting the Interaction between the SH3 Domain of Grb2 and Gab2
(2020) 9 (11), .
11. Bufano, M., Laudette, M., Blondeau, J.-P., Lezoualc’h, F., Nalli, M., Silvestri, R., Brancale, A., Coluccia, A.
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
(2020) 34 (11), pp. 1171-1179.
12. Coluccia, A., Puxeddu, M., Nalli, M., Wei, C.-K., Wu, Y.-H., Mastrangelo, E., Elamin, T., Tarantino, D., Bugert, J.J., Schreiner, B., Nolte, J., Schwarze, F., La Regina, G., Lee, J.-C., Silvestri, R.
Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage
(2020) 11 (10), pp. 1869-1874.
13. La Regina, G., Puxeddu, M., Nalli, M., Vullo, D., Gratteri, P., Supuran, C.T., Nocentini, A., Silvestri, R.
Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors
(2020) 11 (5), pp. 633-637.
14. Capdevielle, C., Desplat, A., Charpentier, J., Sagliocco, F., Thiebaud, P., Thézé, N., Fédou, S., Hooks, K.B., Silvestri, R., Guyonnet-Duperat, V., Petrel, M., Raymond, A.-A., Dupuy, J.-W., Grosset, C.F., Hagedorn, M.
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: Focus on EBP50 and IRSp53
(2020) 22 (4), pp. 550-562.
15. Spizzichino, S., Mattedi, G., Lauder, K., Valle, C., Aouadi, W., Canard, B., Decroly, E., Kaptein, S.J.F., Neyts, J., Graham, C., Sule, Z., Barlow, D.J., Silvestri, R., Castagnolo, D.
Design, Synthesis and Discovery of N,N’-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication
(2020) 15 (4), pp. 385-390.
16. Filipović, N.R., Bjelogrlić, S.K., Pelliccia, S., Jovanović, V.B., Kojić, M., Senćanski, M., La Regina, G., Silvestri, R., Muller, C.D., Todorović, T.R.
Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
(2020) 13 (1), pp. 1466-1489.
17. Laudette, M., Coluccia, A., Sainte-Marie, Y., Solari, A., Fazal, L., Sicard, P., Silvestri, R., Mialet-Perez, J., Pons, S., Ghaleh, B., Blondeau, J.-P., Lezoualc'H, F.
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress
(2019) 115 (12), pp. 1766-1777.
18. Masci, D., Hind, C., Islam, M.K., Toscani, A., Clifford, M., Coluccia, A., Conforti, I., Touitou, M., Memdouh, S., Wei, X., La Regina, G., Silvestri, R., Sutton, J.M., Castagnolo, D.
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies
(2019) 178, pp. 500-514.
19. Cammisotto, V., Carnevale, R., Nocella, C., Stefanini, L., Bartimoccia, S., Coluccia, A., Silvestri, R., Pignatelli, P., Pastori, D., Violi, F.
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin
(2019) 163, pp. 111-118.
20. Coluccia, A., La Regina, G., Naccarato, V., Nalli, M., Orlando, V., Biagioni, S., De Angelis, M.L., Baiocchi, M., Gautier, C., Gianni, S., Di Pastena, F., Di Magno, L., Canettieri, G., Coluccia, A.M.L., Silvestri, R.
Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents
(2019) 10 (4), pp. 499-503.
21. La Regina, G., Coluccia, A., Naccarato, V., Silvestri, R.
Towards modern anticancer agents that interact with tubulin
(2019) 131, pp. 58-68.
22. Puxeddu, M., Shen, H., Bai, R., Coluccia, A., Nalli, M., Mazzoccoli, C., Da Pozzo, E., Cavallini, C., Martini, C., Orlando, V., Biagioni, S., Mazzoni, C., Coluccia, A.M.L., Hamel, E., Liu, T., Silvestri, R., La Regina, G.
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
(2019) art. no. 111828, .
23. Pippa, S., Mannironi, C., Licursi, V., Bombardi, L., Colotti, G., Cundari, E., Mollica, A., Coluccia, A., Naccarato, V., La Regina, G., Silvestri, R., Negri, R.
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B
(2019) 24 (9), art. no. 1739.
