PolyBioMatrix_Lab (CHIM/09)

Attività di ricerca

The research of the group is mainly carried out at the Department of Chemistry and Pharmaceutical Technologies, Faculty of Pharmacy and Medicine, at Sapienza University of Rome, and in collaboration with several Italian and foreign teams.

Schematically, the subjects of the works can be described as follows.

  • Physico-chemical characterization of polysaccharide matrices in solution and in the gel phase. The characterization was finalized to define the nature and type of interactions that occurs between the matrix of polymers and the low molecular weight molecules used. Particular interest was devoted to the characterization of matrices formed by the interpenetration of polysaccharide networks (semi-IPNs and IPNs).
  • Development of innovative systems for drug delivery and of new matrices for tissue engineering applications. These matrices have been studied for their ability to carry and to deliver drugs. In this respect, we used model molecules with different chemical and physico-chemical characteristics. For some of the hydrogel matrices we have also evaluated the ability to act as a biocompatible support for applications in tissue engineering applications.
  • Development of new systems, in the form of "nano" structures based on derivatized polysaccharides to carry and deliver drugs and proteins. In particular, these nanoparticle systems were prepared by self-assembly (bottom-up and top-down mechanisms) of the polysaccharide chains, which were preliminarily derivatized by hydrophobic moieties.
Collaborazioni nazionali e internazionali
  • prof. Wim Hennink, Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, NL;
  • prof. Vladimir Torchilin, Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, USA;
  • prof. Erik Geissler, Laboratoire Interdisciplinaire de Physique CNRS UMR 5588, Université J. Fourier de Grenoble, Grenoble, France;
  • prof. Maria Dolores Veiga, Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain;
  • prof. Pierre Weiss, LIOAD, UMR 791, Faculté d'Odontologie, Nantes, France.;
  • Prof. Cecile Dreiss, Institute of Pharmaceutical Science King's College, London, UK;
  • Prof. Didier Letourneur et Graciela Pavon David, NSERM U1148, Laboratoire de Recherche Vasculaire Translationnelle, Institut Galilée - Université Paris 13, PRES Sorbonne Paris Cité, France;
  • Prof. Fiorenza Rancan, Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité—Universitätsmedizin Berlin, Germany;
  • Prof. Enrique Lallana, Faculty of Biology, Medicine and Health, The University of Manchester, UK;
  • prof. Emanule Pauthe, Institut d'études avancées Maison internationale de la recherche, ERMECCe, Université de Cergy-Pontoise, France.
  • Reometro
  • Dynamic Light Scattering
  • Texture Analyser
  • Microscopio Ottico
  • Viscosimetro Capillare
  • HPLC
  • HPLC-GPC (triple detector)
  • Polarimento
  • UV
  • Spettrofluorimetro, IR, Ultracentrifuga
Settori ERC
  • Medical engineering and technology (LS7_1)
  • Pharmacology, pharmacogenomics, drug discovery and design, drug therapy (LS7_3)
  • Gene therapy, cell therapy, regenerative medicine (LS7_6), Intelligent materials – self assembled materials (PE5_8)

Grants (2019-2022):

  • Finanziamenti di ateneo

Grants (2015-2018):

  • Sapienza University of Rome (Ateneo)
    Grant: RM11715C1743EE89
  • Sapienza University of Rome (Ateneo)
    Grant: RM116154F1B41D9B
  • Sapienza University of Rome (Ateneo)
    Grant: C26A15MH7C
  • Sapienza University of Rome (Ateneo)
    Grant: C26A1432FH
  • Projet EuroNanoMed II: POSTURE
    Grants for industries

Publications (2019-2021)

  • Francesca Di Turo, Pietro Matricardi, Chiara Di Meo, Franco Mazzei, Gabriele Favero, Daniela Zane
    “PVA hydrogel as polymer electrolyte for Electrochemical Impedance analysis on archaeological metals”
    Journal of Cultural Heritage, (2019), 37 113–120 DOI: 10.1016/j.culher.2018.09.017
  • M. Costanzo, F. Vurro, B. Cisterna, F. Boschi, A. Marengo, E. Montanari, C. Di Meo, P. Matricardi, G. Berlier, B. Stella, S. Arpicco, M. Malatesta
    “Uptake and intracellular fate of biocompatible nanocarriers in cycling and non-cycling cells”
    Nanomedicine, (2019), 14, 301-316. DOI 10.2217/nnm-2018-0148
  • E. Montanari, N. Zoratto, L. Mosca, L. Cervoni, E. Lallana, R. Angelini, T. Coviello, C. Di Meo, P. Matricardi
    “Halting hyaluronidase activity with hyaluronan-based particles. Development of smart and versatile injectable materials”
    Carbohydrate Polymers, (2019) 221, 209-220. DOI: 10.1016/j.carbpol.2019.06.004
  • Nicole Zoratto, Isabelle Grillo, Pietro Matricardi, Cecile A. Dreiss,
    Supramolecular gels of cholesterol-modified gellan gum with disc-like and worm-like micelles
    Journal of Colloid and Interface Science, (2019) 556, pp. 301-312. DOI: 10.1016/j.jcis.2019.08.057
  • Elita Montanari, Chiara Di Meo, Tommasina Coviello, Virginie Gueguen, Graciela Pavon-Djavid, Pietro Matricardi
    Intracellular delivery of natural antioxidants via hyaluronan nanohydrogels.
    Pharmaceutics, (2019) 11, 532. DOI: 10.3390/pharmaceutics11100532
  • Giuseppe Gallelli, Erika Cione, Raffaele Serra, Antonio Leo, Rita Citraro, Pietro Matricardi, Chiara Di Meo, Francesco Bisceglia, Maria C. Caroleo, Sonia Basile, Luca Gallelli
    Nano-hydrogel embedded with quercetin and oleic acid as a new formulation in the treatment of diabetic foot ulcer: A pilot study
    International Wound Journal, (2020) 17, 485–490. DOI: 10.1111/iwj.13299
  • Nicole Zoratto, Roberto Matassa, Elita Montanari, Giuseppe Familiari, Stefania Petralito, Tommasina Coviello, Chiara Di Meo, Pietro Matricardi
    Glycerol as a green solvent for enhancing the formulation of dextran methacrylate and gellan-based semi-interpenetrating polymer networks
    Journal of Materials Science, (2020) 55(22), 9562-9577. DOI: 10.1007/s10853-020-04732-1
  • Chiara Genova, Emma Zoppis, Alessandro Grottoli, Claudia Cencetti, Pietro Matricardi, Gabriele Favero
    Integrated approach to the recovery of Travertine biodegradation by combining phyto-cleaning with genomic characterization
    Microchemical Journal, (2020) 156, 104918. DOI: 10.1016/j.microc.2020.104918
  • Elita Montanari; Patrizia Mancini; Filippo Galli; Michela Varani; Iolanda Santino; Tommasina Coviello; Luciana Mosca; Pietro Matricardi; Fiorenza Rancan; Chiara Di Meo
    Biodistribution and intracellular localization of hyaluronan and its nanogels. A strategy to target intracellular S. aureus in persistent skin infections.
    Journal of Controlled Release (2020), 326, 1-12. DOI: https://doi.org/10.1016/j.jconrel.2020.06.007
  • Chiara Di Meo, Tommasina Coviello, Pietro Matricardi, Raffaele Lamanna
    “Anomalous enhanced water diffusion in polysaccharide interpenetrating hydrogels”
    Colloids and Surfaces A, (2021), 613, 125892. DOI: 10.1016/j.colsurfa.2020.125892
  • Franco, Silvia; Buratti, Elena; Ruzicka, Barbara; Nigro, Valentina; Zoratto, Nicole; Matricardi, Pietro; Zaccarelli, Emanuela; Angelini, Roberta
    “Volume fraction determination of microgel composed of interpenetrating polymer networks of PNIPAM and Polyacrylic acid”
    Journal of Physics: Condensed Matter, (2021) 21;33(17). DOI: 10.1088/1361-648X/abe1ec
  • Nicole Zoratto, Laura Forcina, Roberto Matassa, Luciana Mosca, Giuseppe Familiari, Antonio Musarò, Maurizio Mattei, Tommasina Coviello, Chiara Di Meo and Pietro Matricardi
    “Hyaluronan‐Cholesterol Nanogels for the Enhancement of the Ocular Delivery of Therapeutics”
    Pharmaceutics, (2021) 13, 1781. DOI: 10.3390/pharmaceutics13111781


Publications (2015-2018):

1. Chiara Di Meo, Elita Montanari, Lucio Manzi, Claudio Villani, Tommasina Coviello, Pietro Matricardi
“Highly versatile nanohydrogel platform based on riboflavin-polysaccharide derivatives useful in the development of intrinsically fluorescent and cytocompatible drug carriers”
Carbohydrate Polymers, (2015), 502-509. Doi: 10.1016/j.carbpol.2014.08.107
IF = 4.219

2. T. Coviello, A.M. Trotta, C. Marianecci, M. Carafa, L. Di Marzio, F. Rinaldi, C. Di Meo, F. Alhaique, P. Matricardi,
“Gel-embedded niosomes: preparation, characterization and release studies of a new system for topical drug delivery”
Colloids and Surfaces B: Biointerfaces, (2015), 125, 291-299. Doi:10.1016/j.colsurfb.2014.10.060
IF = 3.902

3. Elita Montanari, Maria Cristina De Rugeriis, Chiara Di Meo, Roberta Censi, Tommasina Coviello, Franco Alhaique, Pietro Matricardi*
“One-step formation and sterilization of gellan and hyaluronan nanohydrogels using autoclave”
Journal of Materials Science: Materials in Medicine, (2015), 26 (1), 5362. DOI: 10.1007/s10856-014-5362-6.
IF = 2.272

4. Ines Castangia, Maria Letizia Manca, Pietro Matricardi, Ana Catalán-Latorre, Amparo Nácher, Octavio Diez-Sales, Xavier Fernàndez Busquets, Anna Maria Fadda, Maria Manconi
“Effects of ethanol and diclofenac on the organization of hydrogenated phosphatidylcholine bilayer vesicles and their ability as skin carriers”,
Journal of Materials Science: Materials in Medicine, (2015), 26 (3), 137. DOI 10.1007/s10856-015-5443-1.
IF = 2.272

5. Chiara Di Meo, Felisa Cilurzo, Mariano Licciardi, Cinzia Scialabba, Rocchina Sabia, Donatella Paolino, Donatella Capitani, Massimo Fresta, Gaetano Giammona, Claudio Villani, Pietro Matricardi*
“Polyaspartamide-doxorubicin conjugate as potential prodrug for anticancer therapy”
Pharmaceutical Research, (2015), 32, 1557-1569. DOI: 10.1007/s11095-014-1557-2
IF = 3.260

6. Roberta Censi, Alessandra Dubbini, Pietro Matricardi
"Bioactive hydrogel scaffolds. Advances in cartilage regeneration through controlled drug delivery"
Current Pharmaceutical Design, (2015), 21(12), 1545-55. DOI: 10.2174/1381612821666150115150712
IF = 3.052

7. Davide Bellini, Claudia Cencetti, Joachim Meraner, Daniela Stoppoloni, Anna Scotto D’Abusco, Pietro Matricardi*
“An in situ gelling system for bone regeneration of osteochondral defects.”
European Polymer Journal, (2015), pp. 642-650, DOI http://dx.doi.org/10.1016/j.eurpolymj.2015.02.043
IF = 3.485

8. Franco Alhaique; Pietro Matricardi; Chiara Di Meo; Tommasina Coviello; Elita Montanari
“Polysaccharide-based self-assembling nanohydrogels: an overview on 25-years research on Pullulan”
Journal of Drug Delivery Science and Technology, (2015), 30, 300-309. DOI: 10.1016/j.jddst.2015.06.005
IF = 0.620

9. Tommasina Coviello, Silvia Margheritelli, Pietro Matricardi, Chiara Di Meo, Felice Cerreto, Franco Alhaique, Michela Abrami, Mario Grassi
“Influence of borate amount on the swelling and rheological properties of the Scleroglucan/borax system”
J. Appl. Polym. Sci., (2016), 133, 42860. DOI: 10.1002/APP.42860
IF = 1.860

10. Franco Alhaique; Maria Antonietta Casadei; Claudia Cencetti; Tommasina Coviello; Chiara Di Meo; Pietro
Matricardi; Elita Montanari; Settimio Pacelli; Patrizia Paolicelli
“From macro to nano polysaccharide hydrogels: an opportunity for the delivery of drugs”
Journal of Drug Delivery Science and Technology, (2016) 32, 88-99. DOI: doi:10.1016/j.jddst.2015.09.018
IF = 1.194

11. Maria Letizia Manca, Pietro Matricardi*, Claudia Cencetti, Josè Esteban Peris, Virginia Melis, Claudia Carbone, Elvira Escribano, Marco Zaru, Anna Maria Fadda, Maria Manconi
Combination of argan oil and phospholipids for the development of an effective liposome-like formulation able to improve skin hydration and allantoin dermal delivery” International Journal of Pharmaceutics, (2016), 505, 204–211. DOI: 10.1016/j.ijpharm.2016.04.008
IF = 3.649

12. Davide Bellini, Claudia Cencetti, Anna Cristina Sacchetta, Angela Maria Battista, Andrea Martinelli, Laura Mazzucco, Anna Scotto D’Abusco, Pietro Matricardi*
“PLA-grafting of collagen chains leading to a biomaterial with mechanical performances useful in tendon regeneration” Journal of the Mechanical Behavior of Biomedical Materials, (2016), 64, 151-160. DOI: 10.1016/j.jmbbm.2016.07.006
IF = 3.110

13. Maria Letizia Manca, Claudia Cencetti, Pietro Matricardi*, Ines Castangia, Marco Zaru, Octavio Diez Sales, Amparo Nacher, Donatella Valenti, Anna Maria Maccioni, Anna Maria Fadda, Maria Manconi.
“Glycerosomes: use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration”
International Journal of Pharmaceutics, (2016), 511(1), 198-204. DOI: 10.1016/j.ijpharm.2016.07.009
IF = 3.649

14. Montanari, E., Gennari, A., Pelliccia, M., Gourmel, C., Lallana, E., Matricardi, P., McBain, A.J., Tirelli, N.
Hyaluronan/Tannic Acid Nanoparticles Via Catechol/Boronate Complexation as a Smart Antibacterial System
Macromolecular Bioscience, (2016), 16(12), 1815-1823. DOI 10.1002/mabi.
IF = 3.238

15. Elita Montanari, Chiara Di Meo, Simona Sennato, Antonio Francioso, Anna Laura Marinelli, Francesca Ranzo, Serena Schippa, Tommasina Coviello, Federico Bordi, Pietro Matricardi*
Hyaluronan-cholesterol nanohydrogels: Characterisation and effectiveness in carrying alginate lyase
New Biotechnology, (2017), 37, 80–89. DOI: 10.1016/j.nbt.2016.08.004
IF = 3.813 (2014)

16. Nicole Zoratto, Francesca Romana Palmieri, Claudia Cencetti, Elita Montanari, Chiara Di Meo, Maria Letizia Manca, Maria Manconi, Pietro Matricardi*
Design of hybrid gels based on gellan-cholesterol derivative and P90G liposomes for drug depot applications.
Gels, (2017), 3(2), 18. DOI:10.3390/gels3020018

17. Giuliana Manzi; Nicole Zoratto; Silvia Matano; Rocchina Sabia; Claudio Villani; Tommasina Coviello; Pietro Matricardi; Chiara Di Meo
“Click" hyaluronan based nanohydrogels as multifunctionalizable carriers for hydrophobic drugs
Carbohydrate Polymers, (2017), 174, 706 – 715. DOI 10.1016/j.carbpol.2017.07.003
IF = 4.811 (2016)

18. Maria Letizia Manca, Maria Manconi, Marco Zaru, Donatella Valenti, Jose Esteban Peris, Pietro Matricardi, Anna Maria Maccioni, Anna Maria Fadda
“Glycerosomes: investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances”
International Journal of Pharmaceutics, (2017), 532, 401–407. Doi: 10.1016/j.ijpharm.2017.09.026
IF = 3.649 (2016)

19. M. Zuluaga, G. Gregnanin, C. Cencetti, C. Di Meo, V. Gueguen, D. Letourneur, A. Meddahi-Pellé, G. Pavon-Djavid, P. Matricardi*
“PVA/Dextran hydrogel patches intended for the delivery of the antioxidant astaxanthin in cardiovascular diseases.”
Biomedical Materials, (2018), 13, 015020. Doi: 10.1088/1748-605X/aa8a86
IF = 2.469 (2016)

20. Maria Manconi, Maria Letizia Manca, Carla Caddeo, Donatella Valenti, Claudia Cencetti, Octavio Diez-Sales, Amparo Nacher, Silvia Mir-Palomo, Maria Carmen Terencio, Davide Demurtas, Juan Carmelo Gomez-Fernandez, Francisco José Aranda, Anna Maria Fadda, Pietro Matricardi
“Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin”
Nanomedicine: Nanotechnology, Biology, and Medicine, (2018), 14 (2), 569-579, DOI: 10.1016/j.nano.2017.12.001
IF = 5.720 (2016)

21. Umberto M. Musazzi, Claudia Cencetti, Silvia Franzé, Nicole Zoratto, Chiara Di Meo, Patrizia Procacci, Pietro Matricardi, and Francesco Cilurzo
“Gellan Nanohydrogels: Novel Nanodelivery Systems for Cutaneous Administration of Piroxicam”
Molecular Pharmaceutics. (2018), 15 (3), 1028-1036. DOI: 10.1021/acs.molpharmaceut.7b00926
IF = 4.440 (2016)

22. Maria Manconi, Maria Letizia Manca, Carla Caddeo, Claudia Cencetti, Chiara Di Meo, Nicole Zoratto, Amparo Nacher, Anna Maria Fadda, Pietro Matricardi
“Preparation of gellan-cholesterol nanohydrogels embedding baicalin and evaluation of their wound healing activity”
European Journal of Pharmaceutics and Biopharmaceutics. (2018) 127, 244-249. DOI: 10.1016/j.ejpb.2018.02.015

P23. Elita Montanari, Chiara Di Meo, Angela Oates, Tommasina Coviello, Pietro Matricardi*
“Pursuing intracellular pathogens with hyaluronan. From a ‘pro-infection’ polymer to a biomaterial for ‘Trojan Horse’ systems”
Molecules. (2018), 23, 939. DOI:10.3390/molecules23040939

24. Elita Montanari, Angela Oates, Chiara Di Meo, Josephine Meade, Rugiada Cerrone, Antonio Francioso, Deirdre Devine, Tommasina Coviello, Patrizia Mancini, Luciana Mosca* and Pietro Matricardi*
“Hyaluronan-Based Nanohydrogels for Targeting Intracellular S. aureus in Human Keratinocytes”
Advanced Healthcare Materials. (2018). Accepted

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