LBDT: Lab of Bio-Inspired Devices for Technology (CHIM/09)

Attività di ricerca

The research activity of the group is focused on the development of new polymer- and/or lipid-based systems for biomedical or pharmaceutical applications. It is structured into the following main research lines

1) Synthesis and characterization of novel biopolymers and matrices for application as modified drug delivery systems or as scaffold for tissue engineering
2)Design and development of polymeric thin films for drug delivery
3) Design and development of hybrid drug delivery systems, such as Gel-in-Liposome (GiL) systems -liposomes with a gelled internal core
4)Design and development of stimuli responsive nano-systems for “on demand” drug release

Collaborazioni nazionali e internazionali
  • Dr. Settimio Pacelli, BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, USA
  • Prof. Christian Jungnickel, Department of Colloid and Lipid Science, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland
  • Prof. Francesca Apollonio and prof. Micaela Liberti, Dipartimento di Ingegneria dell’Informazione Elettronica e delle Telecomunicazioni, Sapienza Università di Roma
  • Prof. Maria Cristina Annesini and prof. Alessandra Adrover, Dipartimento di Ingegneria Chimica Materiali Ambiente, Sapienza Università di Roma
  • Dr. Rosanna Pinto e dr. Caterina Merla, Tecnica di Biologia delle Radiazioni e Salute dell'Uomo, ENEA
  • Consultancy activities for Farm srl.
Settori ERC
  • LS7_1 - Medical engineering and technology
  • PE5_4 - Thin films
  • PE5_6 - New materials: oxides, alloys, composite, organic-inorganic hybrid, nanoparticles
  • PE5_7 - Biomaterials synthesis
  • PE5_8 - Intelligent materials - self assembled materials
  • Progetto di Ateneo2015 “Studio formulativo e modellistico per lo sviluppo di film buccali per il rilascio modificato di farmaci”, Progetto di Ateneo
  • Progetto di Ateneo2015 “'The electromagnetic field as actuator of biocompatible nanosystems for drug delivery applications”, Progetto di Ateneo
  • Progetto di Ateneo2016 “'Control of drug release from liposome vesicles using electromagnetic fields”, Progetto di Ateneo
  • Progetto di Ateneo2016 “Integrated approaches for the design and development of homogeneous polymeric strips for buccal delivery of drugs”, Progetto di Ateneo
  • Progetto di Ateneo2017 “Gelation of liposomal internal core for improved drug delivery”, Progetto di Ateneo
  • Progetto di Ateneo2017 “Studio sperimentale e modellistico/computazionale di celle di diffusione per studi di permeazione di formulazioni ad uso topico”, Progetto di Ateneo

Pubblicazioni 2015-2018

1. S. Pacelli, P. Paolicelli, I. Dreesen, S. Kobayashi, A. Vitalone, M. A. Casadei,
“Injectable and photocross-linkable gels based on gellan gum methacrylate: a new tool for  biomedical application”, Int. J. Biol. Macromolecules, 2015, 72, 1335-1342.

2. S. Pacelli, P. Paolicelli, M. A. Casadei,
“New biodegradable dextran-based hydrogels for protein delivery: Synthesis and characterization”,
Carbohydrate Polymers, 2015, 126, 208-2014.

3. R. Spera, F. Apollonio, M. Liberti, A. Paffi, C. Merla, R. Pinto, S. Petralito,
“Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation”,Colloids and Surfaces B: Biointerfaces,2015, 131, 136-140.

4. S. Cesa , M. A. Casadei, F. Cerreto, P. Paolicelli,
“Infant milk formulas: Effect of storage conditions on the stability of powdered products towards
autoxidation”,Foods,2015, 4, 487-500.

5. S. Pacelli, P. Paolicelli, G. Moretti, S. Petralito, S. Di Giacomo, A. Vitalone, M. A. Casadei,
“Gellan gum methacrylate and laponite as an innovative nanocomposite hydrogel for
biomedical applications”, European Polymer Journal, 2016, 77, 114-123.

6. F. Alhaique, M. A. Casadei, C. Cencetti, T. Coviello, C. Di Meo, P. Matricardi, S. Pacelli, P. Paolicelli, “From macro to nano polysaccharide hydrogels: An opportunity for the delivery of drugs” J. Drug Del. Sci. Tech., 2016, 32, 88-99.

7. C. Marianecci, S. Petralito, F. Rinaldi, P. N. Hanieh, M. Carafa,
“Some recent advances on liposomal and niosomal vesicular carriers” J. Drug Del. Sci. Tech., 2016, 32, 256-269

8. S. Petralito, P. Paolicelli, M. Nardoni, F. Apollonio, M. Liberti, C. Merla, R. Pinto, M. A. Casadei, M.C.
Annesini, “Magnetoliposomes: envisioning new strategies for water decontamination”, Chemical  Engineering Transactions, 2016, 47, 37-42.

9. O. Krasodomska, P. Paolicelli, S. Cesa, M. A. Casadei, C. Jungnickel,
“Protection and viability of fruit seeds oils by nanostructured lipid carrier (NLC) nanosuspensions”,
Journal of Colloids and Interface Science, 2016, 479, 25-33.

10. A. Adrover, M.A. Casadei, P. Paolicelli, S. Petralito, G. Varani, “Swelling and drug release from oral thin films (OTFs)”, AIP Conference Proceeding,2016, 1736

11. S. Cesa, S. Carradori, G. Bellagamba, M. Locatelli, M. A. Casadei, A. Masci, P. Paolicelli,
“Evaluation of processing effects on anthocyanin content and colour modifications of blueberry
(Vaccinium spp.) extracts: Comparison between HPLC-DAD and CIELAB analyses”
Food Chemistry, 2017, 232: 114-123

12. P. Paolicelli, G. Varani, S. Pacelli, E. Ogliani, M. Nardoni, S. Petralito, A. Adrover, M.A. Casadei,
“Design and characterization of a biocompatible physical hydrogel based on scleroglucan for topical drug delivery”, Carbohydrate Polymers, 2017, 174: 960-969.

13. A. Masci, S. Carradori, M. A. Casadei, P. Paolicelli, S. Petralito, R. Ragno, S. Cesa“ Lycium barbarum,  polysaccharides: extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review”, Food Chemistry,2018, 254: 377-389

14. M. Nardoni, E. Della Valle, M. Liberti, M. Rilucenti, M. A. Casadei, P. Paolicelli, F. Apollonio, S.  Petralito, “Can pulsed electromagnetic fields trigger on-demand drug release from high-tm
magnetoliposomes?”, Nanomaterials, 2018, 8: 196.

15. S. Pacelli, P. Paolicelli, M. Avitabile, G. Varani, L. Di Muzio, S. Cesa, J. Tirillò, C. Bartuli, M. Nardoni, S. Petralito, A. Adrover, M. A. Casadei, “Design of a tunable nanocomposite double network hydrogel based on gellan gum for drug delivery applications”, Eur. Polymer J. in press.

16. P. Paolicelli, S. Petralito, G. Varani, M. Nardoni, S. Pacelli, J. Tirillò, C. Bartuli, S. Cesa, M. A. Casadei,  A. Adrover, “Effect of glycerol on the physical and mechanical properties of thin gellan gum films for oral drug delivery”, Int. J. Pharmaceutics, in press.

17. A. Patsilinakos, R. Ragno, S. Carradori, S. Petralito, S. Cesa
“Extraction, purification, CIELAB and HPLC-DAD analyses and quantitative correlation of carotenoid content of Goji berries” Food Chem, in press.

18. E. della Valle, M. Liberti, F. Camera, A. Paffi, S. Petralito, V. Roncacè, C. Burattini, G. Aicardi, F.  Apollonio “Versatile exposure system for laboratory experiments finalized to therapeutic  applications in the IF range”, IEEE Journal of Electromagnetics, RF, and Microwaves in Medicine and Biology – Manuscript ID JERM-2018-04-0019, under review.

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