LBDT: Lab of Bio-Inspired Devices for Technology (CHIM/09)

Attività di ricerca

The research activity of the LABORATORY OF BIO-INSPIRED DEVICES FOR TECHNOLOGY is focused on the development of new polymeric- and/or lipid-based systems for biomedical or pharmaceutical applications. The main research lines are:

  1. Synthesis and characterization of bio-polymeric derivatives employed as modified drug delivery systems or as scaffold for tissue engineering
  2. Synthesis and characterization of bio-polymeric derivatives to employ in three-dimensional (3D) bioprinting
  3. Design and development of polymeric thin films for drug delivery
  4. Design and development of hybrid drug delivery systems, such as Gel-in-Liposome (GiL) systems, innovative liposomes with a gelled internal core
  5. Design and development of stimuli responsive nano-systems for “on demand” drug release

The research activity has been devoted to various aspects of modified release (sustained and/or modulated) from matrices prepared with natural polymers such as polysaccharides (scleroglucan, dextran, gellan) and polyaminoacids and their derivatives. In particular, the studies regard the synthesis of new polysaccharidic networks obtained by chemical and/or physical crosslinking among the macromolecular chains, the characterization of their structure and the drug release from dosage formulations prepared with such matrices. Some of these derivatives were also used for 3D printing, to obtain structures suitable for tissue engineering applications. Other studies concern the preparation of polymeric and lipid-based micro- and nanoparticles. This last technology has been used to protect and delivery natural bioactive molecules, usable in pharmaceutical and cosmetic field.

Collaborazioni nazionali e internazionali
  • prof.  Alessandra Adrover, Department of Chemical Engineering Materials, Environmental Engineering DICMA, Università “La Sapienza”
  • prof. Micaela Liberti, Dipartimento di Ingegneria Elettronica dell’Università “La Sapienza” di Roma
  • prof. Francesca Apollonio, Dipartimento di Ingegneria Elettronica dell’Università “La Sapienza” di Roma
  • dr.  Settimio Pacelli, The University of Texas, San Antonio (USA)
  • TA HR 1 rheometer
  • Ztasizer Pro (Malvern Instruments Ltd., Malvern, United Kingdom),
  • 3-D bio-printer BIO X (Cell-Line)
Settori ERC
  • LS7_1 - Medical engineering and technology
  • PE5_4 - Thin films
  • PE5_6 - New materials: oxides, alloys, composite, organic-inorganic hybrid, nanoparticles
  • PE5_7 - Biomaterials synthesis
  • PE5_8 - Intelligent materials - self assembled materials

Pubblicazioni 2019-2021

  1. L Di Muzio, P Paolicelli, C Brandelli, S Cesa, J Trilli, S Petralito, M. A. Casadei, “Injectable and In Situ Gelling Dextran Derivatives Containing Hydrolyzable Groups for the Delivery of Large Molecules”, Gels, 7 (4), 150, 2021
  2. J Trilli, L Caramazza, P Paolicelli, MA Casadei, M Liberti, F Apollonio, S. Petralito, “The Impact of Bilayer Rigidity on the Release from Magnetoliposomes Vesicles Controlled by PEMFs”, Pharmaceutics 13 (10), 1712, 2021
  3. L Di Muzio, F Cienzo, P Paolicelli, S Petralito, S Garzoli, C Brandelli, J. Trilli, M. A. Casadei, “A convenient strategy to synthesize highly tunable gelatin methacryloyl with very low gelation temperature”, European Polymer Journal, 110538, 1, 2021
  4. F Cairone, G Simonetti, A Orekhova, MA Casadei, G Zengin, S Cesa “Health Potential of Clery Strawberries: Enzymatic Inhibition and Anti-Candida Activity Evaluation”,  Molecules 26 (6), 1731,1, 2021
  5. S Pacelli, L Di Muzio, P Paolicelli, V Fortunati, S Petralito, J Trilli, M.A. Casadei,  “Dextran-polyethylene glycol cryogels as spongy scaffolds for drug delivery”,  International Journal of Biological Macromolecules 166, 1292-1300   9, 2021
  6. E Ovidi, VL Masci, AR Taddei, P Paolicelli, S Petralito, J Trilli, M.A. Casadei, “Chemical Investigation and Screening of Anti-Proliferative Activity on Human Cell Lines of Pure and Nano-Formulated Lavandin Essential Oil”,  Pharmaceuticals 13 (11), 352, 2020
  7. A Adrover, L di Muzio, J Trilli, C Brandelli, P Paolicelli, S Petralito, M. A. Casadei, “Enhanced loading efficiency and mucoadhesion properties of gellan gum thin films by complexation with hydroxypropyl-β-cyclodextrin”, Pharmaceutics 12 (9), 819, 3, 2020
  8. S Petralito, P Paolicelli, M Nardoni, J Trilli, L Di Muzio, S Cesa, M. A. Casadei, 2Gelation of the internal core of liposomes as a strategy for stabilization and modified drug delivery I. Physico-chemistry study” International Journal of Pharmaceutics 585, 119467, 1,2020
  9. S Petralito, P Paolicelli, M Nardoni, A Tedesco, J Trilli, L Di Muzio, S Cesa, M. A. Casadei,  “Gelation of the internal core of liposomes as a strategy for stabilization and modified drug delivery II. Theoretical analysis and modelling of in-vitro release experiments”, International Journal of Pharmaceutics 585, 119471, 1, 2020
  10. S Garzoli, S Petralito, E Ovidi, G Turchetti, VL Masci, A Tiezzi, J Trilli, M.A. Casadei, “Lavandula x intermedia essential oil and hydrolate: Evaluation of chemical composition and antibacterial activity before and after formulation in nanoemulsion”, Industrial Crops and Products 145, 112068, 18,      2020
  11. F Cairone, S Carradori, M Locatelli, MA Casadei, S Cesa, “Reflectance colorimetry: A mirror for food quality—A mini review”, European Food Research and Technology 246 (2), 259-272, 13, 2020
  12. S Pacelli, P Paolicelli, S Petralito, S Subham, D Gilmore, G Varani, M.A. Casadei,  “Investigating the role of polydopamine to modulate stem cell adhesion and proliferation on gellan gum-based hydrogels”,  ACS Applied Bio Materials 3 (2), 945-951, 7,       2020
  13. A Adrover, P Paolicelli, S Petralito, L Di Muzio, J Trilli, S Cesa, I Tho, M.A. Casadei, “Gellan gum/laponite beads for the modified release of drugs: Experimental and modeling study of gastrointestinal release”, Pharmaceutics 11 (4), 187, 2019

Pubblicazioni 2015-2018

1. S. Pacelli, P. Paolicelli, I. Dreesen, S. Kobayashi, A. Vitalone, M. A. Casadei,
“Injectable and photocross-linkable gels based on gellan gum methacrylate: a new tool for  biomedical application”, Int. J. Biol. Macromolecules, 2015, 72, 1335-1342.
2. S. Pacelli, P. Paolicelli, M. A. Casadei,
“New biodegradable dextran-based hydrogels for protein delivery: Synthesis and characterization”,
Carbohydrate Polymers, 2015, 126, 208-2014.
3. R. Spera, F. Apollonio, M. Liberti, A. Paffi, C. Merla, R. Pinto, S. Petralito,
“Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation”,Colloids and Surfaces B: Biointerfaces,2015, 131, 136-140.
4. S. Cesa , M. A. Casadei, F. Cerreto, P. Paolicelli,
“Infant milk formulas: Effect of storage conditions on the stability of powdered products towards
autoxidation”,Foods,2015, 4, 487-500.
5. S. Pacelli, P. Paolicelli, G. Moretti, S. Petralito, S. Di Giacomo, A. Vitalone, M. A. Casadei,
“Gellan gum methacrylate and laponite as an innovative nanocomposite hydrogel for
biomedical applications”, European Polymer Journal, 2016, 77, 114-123.
6. F. Alhaique, M. A. Casadei, C. Cencetti, T. Coviello, C. Di Meo, P. Matricardi, S. Pacelli, P. Paolicelli, “From macro to nano polysaccharide hydrogels: An opportunity for the delivery of drugs” J. Drug Del. Sci. Tech., 2016, 32, 88-99.
7. C. Marianecci, S. Petralito, F. Rinaldi, P. N. Hanieh, M. Carafa,
“Some recent advances on liposomal and niosomal vesicular carriers” J. Drug Del. Sci. Tech., 2016, 32, 256-269
8. S. Petralito, P. Paolicelli, M. Nardoni, F. Apollonio, M. Liberti, C. Merla, R. Pinto, M. A. Casadei, M.C.
Annesini, “Magnetoliposomes: envisioning new strategies for water decontamination”, Chemical  Engineering Transactions, 2016, 47, 37-42.
9. O. Krasodomska, P. Paolicelli, S. Cesa, M. A. Casadei, C. Jungnickel,
“Protection and viability of fruit seeds oils by nanostructured lipid carrier (NLC) nanosuspensions”,
Journal of Colloids and Interface Science, 2016, 479, 25-33.
10. A. Adrover, M.A. Casadei, P. Paolicelli, S. Petralito, G. Varani, “Swelling and drug release from oral thin films (OTFs)”, AIP Conference Proceeding,2016, 1736
11. S. Cesa, S. Carradori, G. Bellagamba, M. Locatelli, M. A. Casadei, A. Masci, P. Paolicelli,
“Evaluation of processing effects on anthocyanin content and colour modifications of blueberry
(Vaccinium spp.) extracts: Comparison between HPLC-DAD and CIELAB analyses”
Food Chemistry, 2017, 232: 114-123
12. P. Paolicelli, G. Varani, S. Pacelli, E. Ogliani, M. Nardoni, S. Petralito, A. Adrover, M.A. Casadei,
“Design and characterization of a biocompatible physical hydrogel based on scleroglucan for topical drug delivery”, Carbohydrate Polymers, 2017, 174: 960-969.
13. A. Masci, S. Carradori, M. A. Casadei, P. Paolicelli, S. Petralito, R. Ragno, S. Cesa“ Lycium barbarum,  polysaccharides: extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review”, Food Chemistry,2018, 254: 377-389
14. M. Nardoni, E. Della Valle, M. Liberti, M. Rilucenti, M. A. Casadei, P. Paolicelli, F. Apollonio, S.  Petralito, “Can pulsed electromagnetic fields trigger on-demand drug release from high-tm
magnetoliposomes?”, Nanomaterials, 2018, 8: 196.
15. S. Pacelli, P. Paolicelli, M. Avitabile, G. Varani, L. Di Muzio, S. Cesa, J. Tirillò, C. Bartuli, M. Nardoni, S. Petralito, A. Adrover, M. A. Casadei, “Design of a tunable nanocomposite double network hydrogel based on gellan gum for drug delivery applications”, Eur. Polymer J. in press.
16. P. Paolicelli, S. Petralito, G. Varani, M. Nardoni, S. Pacelli, J. Tirillò, C. Bartuli, S. Cesa, M. A. Casadei,  A. Adrover, “Effect of glycerol on the physical and mechanical properties of thin gellan gum films for oral drug delivery”, Int. J. Pharmaceutics, in press.
17. A. Patsilinakos, R. Ragno, S. Carradori, S. Petralito, S. Cesa
“Extraction, purification, CIELAB and HPLC-DAD analyses and quantitative correlation of carotenoid content of Goji berries” Food Chem, in press.
18. E. della Valle, M. Liberti, F. Camera, A. Paffi, S. Petralito, V. Roncacè, C. Burattini, G. Aicardi, F.  Apollonio “Versatile exposure system for laboratory experiments finalized to therapeutic  applications in the IF range”, IEEE Journal of Electromagnetics, RF, and Microwaves in Medicine and Biology – Manuscript ID JERM-2018-04-0019, under review.

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma