Organic Chemistry (CHIM/06)

Attività di ricerca

Sintesi di recettori artificiali per applicazioni nel campo della biosensoristica e del drug delivery
Sintesi di sistemi a base resorc[4]arenica come nuovi linker artificiali per l’immobilizzazione sito-diretta di anticorpi nello sviluppo di immunosensori e biosensori
Isolamento, biotrasformazione, elucidazione strutturale e sintesi di composti biologicamente attivi da piante medicinali
Scoperta e sviluppo di piccole molecole organiche e/o composti naturali per il targeting selettivo di vie di segnalazione iperattivate in cellule staminali tumorali (ad esempio, vie di segnalazione di Hedgehog e Notch)
Sintesi di sonde fluorescenti selettive sulla proteina tau per la diagnosi precoce della malattia di Alzheimer
Progettazione e sintesi di linker carichi positivamente per lo sviluppo di farmaci bioconiugati con potenziale applicazione nella nanomedicina e nel campo della diagnostica
Coltivazione di canapa industriale (Cannabis Sativa L.) e caratterizzazione dei fitocomponenti

Collaborazioni nazionali e internazionali

Al-Jamal K. (King’s College London);
Ascenzioni F. (Sapienza University, Department of Biology and Biotechnology, Italy);
Boffi A. (Sapienza University, Department of Biochemistry, Italy);
Mazzei F. (Sapienza University, Department of Chemistry and Technology of Drugs, Italy);
Mori M. (University of Siena, Department of Biotechnology, Chemistry and Pharmacy, Italy);
Caliceti P. (University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Italy)
Damia G. (Mario Negri Institute for Pharmacological Research, Italy)
Di Marcotullio L. (Sapienza University, Department of Molecular Medicine, Italy)
Glisic S. (Institute of Nuclear Sciences, Serbia)
Limatola C. (Sapienza University, Department of Physiology and Pharmacoloy, Italy)
Mancia F. (Columbia University, Department of Physiology and Cellular Biophysics, USA)
Mannina L. (Sapienza University, Department of Chemistry and Technology of Drugs, Italy)
Schneider G. (Karolinska Institutet, Sweden)
Screpanti I. (Sapienza University, Department of Molecular Medicine, Italy)
Terenzi H. (Universidade Federal de Santa Catarin, Brasil)
Turano P. (CERM University of Florence, Italy)
Ulukaya E. (Medical School of Uludag University, Turkey)
Loscalzo J. (Medical School of Harvard University, USA)
Athanassopoulos C. (University of Patras, Greece)
Mangei J. (German Cancer Research Center, DKFZ, German

Strumentazione

UHPLC Thermoscientific Dionex Ultimate 3000 series con autocampionatore e rivelatore UV diode array e accoppiato con spettrometro di massa Thermoscientific MSQ Plus con sorgenti ESI e API, analizzatore triplo quadrupolo
Buchi Pure C-850 cromatografo Flash e HPLC semipreparativo con rivelatori UV e ELSD
Bruker Av-400 400 MHz NMR spectrometer (Dipartimentale)

Settori ERC

PE5_16 - Supramolecular chemistry
PE5_17 - Organic chemistry
LS4_12 - Cancer

Finanziamenti

MIUR, PON (Piano Operativo Nazionale) (2018-2020)

Pubblicazioni

Publication (2019-2021)

Buonsenso, F., Ghirga, F., Romeo, I., Siani, G., Pilato, S., Quaglio, D., Pierini, M., Botta, B., Calcaterra, A. Exploring the Assembly of Resorc[4]arenes for the Construction of Supramolecular Nano-Aggregates. Int. J. Mol. Sci. 2021, 22, 11785.
Mangoni, M. L., Bhunia, A., Botta, B., Ghirga F. Editorial: Secondary Metabolites and Peptides as Unique Natural Reservoirs of New Therapeutic Leads for Treatment of Cancer and Microbial Infections Front. Chem. 2021, 9, art. no. 748180.
Platella, C., Ghirga, F., Zizza, P., Pompili, L., Marzano, S., Pagano, B., Quaglio, D., Vergine, V., Cammarone, S., Botta, B., Biroccio, A., Mori, M., Montesarchio, D. Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds. Pharmaceutics 2021, 13 (10), art. no. 1611.
Schafroth, M. A., Mazzoccanti, G., Reynoso-Moreno, I., Erni, R., Pollastro, F., Caprioglio, D., Botta, B., Allegrone, G., Grassi, G., Chicca, A., Gasparrini, F., Gertsch, J., Carreira, E. M., Appendino, G. Δ9-cis-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology. J. Nat. Prod. 2021, 84 (9), 2502−2510.
D’Alessandro, G., Lauro, C., Quaglio, D., Ghirga, F., Botta, B., Trettel, F., Limatola, C. Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma. Cancers 2021, 13 (11), art. no. 2810.
Spano, M., Di Matteo, G., Ingallina, C., Botta, B., Quaglio, D., Ghirga, F., Balducci, S., Cammarone, S., Campiglia, E., Giusti, A. M., Vinci, G., Rapa, M., Ciano, S., Mannina, L., Sobolev, A. P. A Multimethodological Characterization of Cannabis sativa L. Inflorescences from Seven Dioecious Cultivars Grown in Italy: The Effect of Different Harvesting Stages. Molecules 2021, 26 (10), art. no. 2912.
Zheng, Y., Yang, X.-W., Schols, D., Mori, M., Botta, B., Chevigné, A., Mulinge, M., Steinmetz, A., Schmit, J.-C., Seguin-Devaux C. Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action. Int. J. Mol. Sci. 2021, 22 (9), art. no. 5052.
Bonandi, E., Mori, M., Infante, P., Basili, I., Di Marcotullio, L., Calcaterra, A., Catti, F., Botta, B., Passarella, D. Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors. Chem. Eur. J. 2021, 27 (32), pp 8350–8357.
Pediconi, N., Ghirga, F., Del Plato, C., Peruzzi, G., Athanassopoulos, C. M., Mori, M., Crestoni, M. E., Corinti, D., Ugozzoli, F., Massera, C., Arcovito, A., Botta, B., Boffi, A., Quaglio, D., Baiocco, P. Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells. Bioconjugate Chem. 2021, 32 (6), pp 1105−1116.
Ghirga, F., Quaglio, D., Mori, M., Cammarone, S., Iazzetti, A., Goggiamani, A., Ingallina, C., Botta B., Calcaterra, A. A unique high-diversity natural product collection as a reservoir of new therapeutic leads. Organic Chemistry Frontiers 2021, 8 (5), pp 996-1025.
Infante, P., Malfanti, A., Quaglio, D., Balducci, S., De Martin, S., Bufalieri, F., Mastrotto, F., Basili, I., Garofalo, M., Lospinoso Severini, L., Mori, M., Manni, I., Moretti, M., Nicoletti, C., Piaggio, G., Caliceti, P., Botta, B., Ghirga, F., Salmaso, S., Di Marcotullio, L. Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma. Cancer Letters 2021, 499, pp. 220-231.
Petrović, M. M., Roschger, C., Chaudary, S., Zierer, A., Mladenović, M., Jakovljević, K., Marković, V., Botta, B., Joksović, M.D. Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies. Bioorganic Chemistry 2020, 105, art. no. 104373.
Caggiano, C., Guida, E., Todaro, F., Bielli, P., Mori, M., Ghirga, F., Quaglio, D., Botta, B., Moretti, F., Grimaldi, P., Rossi, P., Jannini, E.A., Barchi, M., Dolci, S. Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells. Cell Death Discovery 2020, 6 (1), art. no. 111.
Montone, C.M., Cerrato, A., Botta, B., Cannazza, G., Capriotti, A.L., Cavaliere, C., Citti, C., Ghirga, F., Piovesana, S., Laganà, A. Improved identification of phytocannabinoids using a dedicated structure-based workflow. Talanta 2020, 219, 121310.
Quaglio, D., Mangoni, M.L., Stefanelli, R., Corradi, S., Casciaro, B., Vergine, V., Lucantoni, F., Cavinato, L., Cammarone, S., Loffredo, M.R., Cappiello, F., Calcaterra, A., Erazo, S., Ghirga, F., Mori, M., Imperi, F., Ascenzioni, F., Botta, B. Ent-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors. Journal of Organic Chemistry 2020, 85 (16), pp. 10891-10901.
Casciaro, B., Mangiardi, L., Cappiello, F., Romeo, I., Loffredo, M.R., Iazzetti, A., Calcaterra, A., Goggiamani, A., Ghirga, F., Mangoni, M.L., Botta, B., Quaglio, D. Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections. Molecules 2020, 25 (16), art. no. 3619.
Quaglio, D., Mangiardi, L., Venditti, G., Del Plato, C., Polli, F., Ghirga, F., Favero, G., Pierini, M., Botta, B., Mazzei, F. Site-Directed Antibody Immobilization by Resorc[4]arene-Based Immunosensors. Chemistry - A European Journal 2020, 26 (38), pp. 8400-8406.
Cappiello, F., Loffredo, M.R., Plato, C.D., Cammarone, S., Casciaro, B., Quaglio, D., Mangoni, M.L., Botta, B., Ghirga, F. The revaluation of plant-derived terpenes to fight antibiotic-resistant infections. Antibiotics 2020, 9 (6), art. no. 325.
Maj, P., Mori, M., Sobich, J., Markowicz, J., Uram, Ł., Zielinski, Z., Quaglio, D., Calcaterra, A., Cau, Y., Botta, B., Rode, W. Alvaxanthone, a thymidylate synthase inhibitor with nematocidal and tumoricidal activities. Molecules 2020, 25 (12), 2894.
Quaglio, D., Corradi, S., Erazo, S., Vergine, V., Berardozzi, S., Sciubba, F., Cappiello, F., Crestoni, M.E., Ascenzioni, F., Imperi, F., Delle Monache, F., Mori, M., Loffredo, M.R., Ghirga, F., Casciaro, B., Botta, B., Mangoni, M.L. Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from Fabiana densa var. ramulosa. ACS Medicinal Chemistry Letters 2020, 11 (5), pp. 760-765.
Diukendjieva, A., Zaharieva, M.M., Mori, M., Alov, P., Tsakovska, I., Pencheva, T., Najdenski, H., Křen, V., Felici, C., Bufalieri, F., Di Marcotullio, L., Botta, B., Botta, M., Pajeva, I. Dual smo/braf inhibition by flavonolignans from silybum marianum. Antioxidants 2020, 9 (5), art. no. 384.
Quaglio, D., Infante, P., Di Marcotullio, L., Botta, B., Mori, M. Hedgehog signaling pathway inhibitors: an updated patent review (2015–present). Expert Opinion on Therapeutic Patents 2020, 30 (4), pp. 235-250.
Ourabah, A., Atmani-Kilani, D., Debbache-Benaida, N., Kolesova, O., Azib, L., Yous, F., Benloukil, M., Botta, B., Atmani, D., Simonetti, G. Anti-Candida albicans biofilm activity of extracts from two selected indigenous Algerian plants: Clematis flammula and Fraxinus angustifolia. Journal of Herbal Medicine 2020, 20, 100319.
Ingallina, C., Sobolev, A.P., Circi, S., Spano, M., Fraschetti, C., Filippi, A., Di Sotto, A., Di Giacomo, S., Mazzoccanti, G., Gasparrini, F., Quaglio, D., Campiglia, E., Carradori, S., Locatelli, M., Vinci, G., Rapa, M., Ciano, S., Giusti, A.M., Botta, B., Ghirga, F., Capitani, D., Mannina, L. Cannabis sativa L. inflorescences from monoecious cultivars grown in central Italy: An untargeted chemical characterization from early flowering to ripening. Molecules 2020, 25 (8), 1908.
Calcaterra, A., Mangiardi, L., Monache, G.D., Quaglio, D., Balducci, S., Berardozzi, S., Iazzetti, A., Franzini, R., Botta, B., Ghirga, F. The pictet-spengler reaction updates its habits. Molecules 2020, 25 (2), 414.
Cirigliano, A., Amelina, A., Biferali, B., Macone, A., Mozzetta, C., Bianchi, M.M., Mori, M., Botta, B., Pick, E., Negri, R., Rinaldi, T. Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35 (1), pp. 129-137.
Ghirga, F., Stefanelli, R., Cavinato, L., Lo Sciuto, A., Corradi, S., Quaglio, D., Calcaterra, A., Casciaro, B., Loffredo, M.R., Cappiello, F., Morelli, P., Antonelli, A., Rossolini, G.M., Mangoni, M., Mancone, C., Botta, B., Mori, M., Ascenzioni, F., Imperi, F. A novel colistin adjuvant identified by virtual screening for ArnT inhibitors. Journal of Antimicrobial Chemotherapy 2020, 75 (9), pp. 2564-2572.
Mori, M., Manetti, F., Botta, B., Tafi, A. In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design. Journal of Chemical Information and Modeling 2019, 59 (12), pp. 4961-4967.
D. Corinti; A. Maccelli; M.E. Crestoni; S. Cesa; D. Quaglio; B. Botta; C. Ingallina; L. Mannina; A. Tintaru; B. Chiavarino; S. Fornarini. IR ion spectroscopy in a combined approach with MS/MS and IM-MS to discriminate epimeric anthocyanin glycosides (cyanidin 3-O-glucoside and -galactoside). International Journal of Mass Spectrometry 2019, 444, 116179.
L.L. Severini; D. Quaglio; I. Basili; F. Ghirga; F. Bufalieri; M. Caimano; S. Balducci; M. Moretti; I. Romeo; E. Loricchio; M. Maroder; B. Botta; M. Mori; P. Infante; L. Di Marcotullio. A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth. Cancers 2019, 11:1518.
B. Casciaro, A. Calcaterra, F. Cappiello, M. Mori, M.R. Loffredo, F. Ghirga, M.L. Mangoni, B. Botta, D. Quaglio. Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus Aureus-Induced Infections. Toxins (Basel) 2019, 11 (9), 511.
G. D'Alessandro; D. Quaglio, L. Monaco; C. Lauro; F. Ghirga; C. Ingallina; M. De Martino; S. Fucile; A. Porzia; M.A. Di Castro; F. Bellato; F. Mastrotto; M. Mori; P. Infante; P. Turano; S. Salmaso; P. Caliceti; L. Di Marcotullio; B. Botta; V. Ghini; C. Limatola. 1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma. Cell Communication and Signaling 2019, 17, 108.
K. Jakovljević; M.D. Joksović; B. Botta; L.S. Jovanović; E. Avdović; Z. Marković; V. Mihailović;
M. Andrić; S. Trifunović; V. Marković. Novel 1, 3, 4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies. Comptes Rendus Chimie 2019, 22 (8), pp. 585-598.
D. Quaglio; N. Zhdanovskaya; G. Tobajas; V. Cuartas; S. Balducci; M. S. Christodoulou; G. Fabrizi; M. Gargantilla; E.-M. Priego;Á. C. Pestaña; D. Passarella; I. Screpanti; B. Botta; R. Palermo; M. Mori; F. Ghirga; M.-J. Pérez-Pérez. Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia. ACS Med. Chem. Lett. 2019, 10 (4), pp. 639-643.
Savoia, M., Cencioni, C., Mori, M., Atlante, S., Zaccagnini, G., Devanna, P., Di Marcotullio, L., Botta, B., Martelli, F., Zeiher, A.M., Pontecorvi, A., Farsetti, A., Spallotta, F., Gaetano, C. P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation. The FASEB Journal 2019, 33 (3), pp. 4107-4123.

Pubblication 2015-2018

1. Sobolev, A.P., Mannina, L., Capitani, D., Sanzò, G., Ingallina, C., Botta, B., Fornarini, S., Crestoni, M.E., Chiavarino, B., Carradori, S., Locatelli, M., Giusti, A.M., Simonetti, G., Vinci, G., Preti, R., Toniolo, C., Reverberi, M., Scarpari, M., Parroni, A., Abete, L., Natella, F., Di Sotto, A. A multi-methodological approach in the study of Italian PDO “Cornetto di Pontecorvo” red sweet pepper (2018) Food Chemistry, 255, 120-131.

2. Cevatemre, B., Erkisa, M., Aztopal, N., Karakas, D., Alper, P., Tsimplouli, C., Sereti, E., Dimas, K., Armutak, E.I.I., Gurevin, E.G., Uvez, A., Mori, M., Berardozzi, S., Ingallina, C., D’Acquarica, I., Botta, B., Ozpolat, B., Ulukaya, E. A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer. Pharmacological Research (2018), 129, 500-514.

3. Mascarello, A., Orbem Menegatti, A.C., Calcaterra, A., Martins, P.G.A., Chiaradia-Delatorre, L.D., D’Acquarica, I., Ferrari, F., Pau, V., Sanna, A., De Logu, A., Botta, M., Botta, B., Terenzi, H., Mori, M. Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B. European Journal of Medicinal Chemistry 2017, 144, 277-288

4. Spallotta, F., Cencioni, C., Atlante, S., Garella, D., Cocco, M., Mori, M., Mastrocola, R., Kuenne, C., Guenther, S., Nanni, S., Azzimato, V., Zukunft, S., Kornberger, A., Sürün, D., Schnütgen, F., Von Melchner, H., Di Stilo, A., Aragno, M., Braspenning, M., Van Criekinge, W., De Blasio, M.J., Ritchie, R.H., Zaccagnini, G., Martelli, F., Farsetti, A., Fleming, I., Braun, T., Beiras-Fernandez, A., Botta, B., Collino, M., Bertinaria, M., Zeiher, A.M., Gaetano, C. Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation (2018) Circulation Research, 122 (1),31-46.

5. Calcaterra, A., Iovine, V., Botta, B., Quaglio, D., D’Acquarica, I., Ciogli, A., Iazzetti, A., Alfonsi, R., Lospinoso Severini, L., Infante, P., Di Marcotullio, L., Mori, M., Ghirga, F. Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61 (2018) Journal of Enzyme Inhibition and Medicinal Chemistry, 33 (1), pp. 349-358.

6. Al Sharif, M., Alov, P., Vitcheva, V., Diukendjieva, A., Mori, M., Botta, B., Tsakovska, I., Pajeva, I. Natural modulators of nonalcoholic fatty liver disease: Mode of action analysis and in silico ADME-Tox prediction. Toxicology and Applied Pharmacology 2017, 337, 45-66.

7. Mori, M., Tottone, L., Quaglio, D., Zhdanovskaya, N., Ingallina, C., Fusto, M., Ghirga, F., Peruzzi, G., Crestoni, M.E., Simeoni, F., Giulimondi, F., Talora, C., Botta, B., Screpanti, I., Palermo, R. Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia. Scientific Reports 2017, 7, 2213.

8. Ghirga, F., Bonamore, A., Calisti, L., D’Acquarica, I., Mori, M., Botta, B., Boffi, A., Macone, A. Green routes for the production of enantiopure benzylisoquinoline alkaloids. International Journal of Molecular Sciences 2017, 18 (11), 2464.

9. Pingwara, R., Witt-Jurkowska, K., Ulewicz, K., Mucha, J., Tonecka, K., Pilch, Z., Taciak, B., Zabielska-Koczywas, K., Mori, M., Berardozzi, S., Botta, B., Rygiel, T.P., Krol, M. Interferon lambda 2 promotes mammary tumor metastasis via angiogenesis extension and stimulation of cancer cell migration. Journal of Physiology and Pharmacology 2017, 68 (4), 573-583.

10. Ingallina, C., Costa, P.M., Ghirga, F., Klippstein, R., Wang, J.T., Berardozzi, S., Hodgins, N., Infante, P., Pollard, S.M., Botta, B., Al-Jamal, K.T. Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro. Nanomedicine 2017, 12 (7), 711-728.

11. Alfonsi, R., Botta, B., Cacchi, S., Di Marcotullio, L., Fabrizi, G., Faedda, R., Goggiamani, A., Iazzetti, A., Mori, M. Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway. Journal of Medicinal Chemistry 2017, 60 (4), 1496-1477.

12. Aiello, F., Balzano, F., Ghirga, F., D’Acquarica, I., Botta, B., Uccello-Barretta, G., Quaglio, D. First detection of a Ruthenium-carbene-resorc[4]arene complex during the progress of a metathesis reaction. EUR Journal of Organic Chemistry 2017, 17, 2407-2415.

13. Evain-Bana, E., Schiavo, L., Bour, C., Lanfranchi, D-A, Berardozzi, S., Ghirga, F., Bagrel, D., Botta, B., Hanquet, G., Mori, M. Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases. Journal of enzyme inhibition and medicinal chemistry 2017, 32(1),113-118.

14. Zwergel, C., Czepukojc, B., Evain-Bana, E., Xu, Z., Stazi, G., Mori, M., Patsilinakos, A., Mai, A., Botta, B., Ragno, R., Bagrel, D., Kirsch, G., Meiser, P., Jacob, C., Montenarh, M., Valente, S. Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells. European Journal of Medicinal Chemistry 2017, 134, 316-333.

15. Sobolev, A.P., Mannina, L., Aru, V., Bellomaria, A., Bertocchi, F., Botta, B., Cagliani, L.R., Caligiani, A., Capozzi, F., Çela, D., Marincola, F.C., Ciampa, A., Del Coco, L., Consonni, R., Corsaro, C., Delfini, M., Di Tullio, V., Fanizzio, F.P., Gallo, V., Ghirga, F., Gianferri, R., Girellio, C.R., Ingallina, C., Laghi, L., Latronico, M., Longobardi, F., Luchinat, C., Mallamace, D., Mammi, S., Mandaliti, W., Marini, F., Mastrorilli, P., Mazzei, P., Miccheli, A., Micozzio, A., Miloneo, S., Mucci, A., Nepravishta, R., Paci, M., Palisi, A., Piccolo, A., Picone, G., Proietti, N., Randazzo, A., Righi, V., Rotondo, A., Salvo, A., Savorani, F., Scano, P., Schievano, E., Sciubba, F., Tenori, L., Trimigno, A., Turano, P., Vasi, S., Capitani, D. NMR applications in food analysis: Part A (2017) Analytical Chemistry: Developments, Applications and Challenges in Food Analysis, pp. 157-253.

16. Proietti, N., Capitani, D., Aru, V., Bellomaria, A., Bertocchi, F., Botta, B., Cagliani, L.R., Caligiani, A., Capozzi, F., Çela, D., Marincola, F.C., Ciampa, A., Coco, L.D., Consonni, R., Corsaro, C., Delfini, M., Fanizzio, F.P., Gallo, V., Ghirga, F., Gianferri, R., Girellio, C.R., Ingallina, C., Laghi, L., Latronico, M., Longobardi, F., Luchinat, C., Mallamace, D., Mammi, S., Mandaliti, W., Mannina, L., Marini, F., Mastrorilli, P., Mazzei, P., Miccheli, A., Micozzio, A., Miloneo, S., Mucci, A., Nepravishta, R., Paci, M., Palisi, A., Sobolev, A.P., Piccolo, A., Picone, G., Randazzo, A., Righi, V., Rotondo, A., Salvo, A., Savorani, F., Scano, P., Schievano, E., Sciubba, F., Tenori, L., Trimigno, A., Turano, P., Vasi, S., Tullio, V.D. NMR applications in food analysis: Part B (2017) Analytical Chemistry: Developments, Applications and Challenges in Food Analysis, pp. 255-296.

17. Iovine, V., Benni, I., Sabia, R., D’Acquarica, I., Fabrizi, G., Botta, B., Calcaterra, C. Total Synthesis of (±)-Kuwanol E. Journal of Natural Product 2016, 79 (10), pp. 2495-2503.

18. Cevatemre, B., Botta, B., Mori, M., Berardozzi, S., Ingallina, C., Ulukaya, E. The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Chemico-Biological Interactions 2016, 260, pp. 248-255.

19. Infante, P., Alfonsi, R., Ingallina, C., Quaglio, D., Ghirga, F., D’Acquarica, I., Di Magno, L., Canettieri, G., Screpanti, I., Gulino, A., Botta, B., Mori, M., Di Marcotullio, L. Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype. Cell Death & Disease 2016, 7, e2376.

20. Ingallina, C., Rinaldi, F., Bogni, A., Ponti, J., Passeri, D., Reggente, M., Rossi, M., Kinsner-Ovaskainen, A.; Mehn, D., Rossi, F., Botta, B., Carafa, M., Marianecci, C. Niosomal approach to brain delivery: Development, characterization and in vitro toxicological studies. International journal of pharmaceutics 2016, 511 (2), pp.969-982.

21. Barretta, G. U., Balzano, F., Aiello, F., Nardelli, F., Ciogli, A., Calcaterra, A., Botta, B. Covalently assembled resorcin[4]arenes and molecular tweezers: a chiral recognition rationale by NMR. Supramolecular chemistry 2016, 21 (7-8), pp. 647-655.

22. Ghirga, F., Quaglio, D., Ghirga, P., Berardozzi, S., Zappia, G., Botta, B., Mori, M., D’Acquarica, I. Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine. Chirality 2016, 28 (3), pp. 169-180.

23. Comba, A., Ainnada, L. L., Tolosa, E. J., Iguchi, E., Marks, D. L., Messler, M. V., Silva, R., Fernandez-Barrena, M. G., Enriquez-Hesles, E., Vrabel, A. L., Botta, B., Di Marcotulio, L., Ellenrieder, V., Eynard, A. R., Pasqualini, M. E., Fernandez-Zapico, M. E. Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid. Journal of biological chemistry 2016, 291 (4), pp. 1933-1947.

24. Bonamore, A., Calisti, L., Calcaterra, A., Ismail, O.H., Gargano, M., D’Acquarica, I., Botta, B., Boffi, A., Macone, A. A Novel Enzymatic Strategy for the Synthesis of Substituted Tetrahydroisoquinolines. Chemistry Select 2016, 1 (8), pp. 1933-1947.

25. Cirigliano, A., Stirpe, A., Menta, S., Mori, M., Dell’Edera, D., Pick, E., Negri, R., Botta, B., Rinaldi, T. Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5. Journal of enzyme inhibition and medicinal chemistry 2016, 31 (6), pp. 1632-1637.

26. Navakauskiene, R., Mori, M., Christodoulou, M. S., Zentelyte, A., Botta, B., Dalla Via, L., Ricci, F., Damia, G., Passarella, D., Zilio, C., Martinet, N. Histone demethylating agents as potential S-adenosyl-L-methionine-competitors. Medicinal Chemical Communications 2016, 7 (6), pp. 1245-1255.

27. Mascarello, A., Chiaradia-Delatorre, L. D., Mori, M., Terenzi, H., Botta, B. Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs. Current pharmaceutical design 2016, 22 (12), pp. 1561-1569.

28. D’Acquarica, I., Ghirga, F., Ingallina, C., Quaglio, D., Zappia, G., Uccello-Barretta, G., Balzano, F., Botta, B. Resorc[4]arenes as preorganized synthons for surface recognition and host-guest chemistry. In book: Calixarenes and Beyond 2016, pp. 175-193.

29. Iovine, V., Mori, M., Calcaterra, A., Berardozzi, S., Botta, B. One Hundred Faces of Cyclopamine. Current pharmaceutical design 2016, 22 (12), pp. 1658-1681.

30. D’Acquarica, I., Ghirga, F., Quaglio, D., Cerreto, A., Ingallina, C., Tafi, A., Botta, B. Molecular Recognition of Natural Products by Resorc[4]arene Receptors. Current pharmaceutical design (2016), 22 (12), pp. 1715-1729.

31. Khan, M. I., Sobocinska, A. A., Czarnecka, A. M., Krol, M., Botta, B., Szczylik, C. The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory. Current pharmaceutical design 2016, 22 (12), pp. 1756-1766.

32. Ingallina, C., D’Acquarica, I., Monache, G.D., Ghirga, F., Quaglio, D., Ghirga, P., Berardozzi, S., Markovic, V., Botta, B., The pictet-spengler reaction still on stage. Current Pharmaceutical Design 2016, 22 (12), pp. 1808-1850.

33. Esposito, F., Tintori, C., Martini, R., Christ, F., Debyser, Z., Ferrarese, R., Cabiddu, G., Corona, A., Ceresola, E. R., Calcaterra, A., Iovine, V., Botta, B., Clementi, M., Canducci, F., Botta, M., Tramontano, E. Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation. ChemBioChem 2015, 16 (17), pp. 2507-2512.

34. Martins, P. G. A., Mori, M., Chiaradia-Delatorre, L. D., Menegatti, A. C. O., Mascarello, A., Botta, B., Benitez, J., Gambino, D., Terenzi, H. Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies. ACS Medicinal Chemistry Letters 2015, 6 (10), pp. 1035-1040.

35. Christodoulou, M. S., Mori, M., Pantano, R., Alfonsi, R., Infante, P., Botta, M., Damia, G., Ricci, F., Sotiropoulou, P. A., Liekens, S., Botta, B., Passarella, D. Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib. ChemPlusChem 2015, 80(6), pp. 938-943.

36. Infante, P., Alfonsi, R., Botta, B., Mori, M., Di Marcotullio, L. Targeting Gli factors to inhibit the Hedgehog pathway. Trends in Pharmacological Sciences 2015, 36(8), pp. 547-558.

37. Infante, P., Mori, M., Alfonsi, R., Ghirga, F., Aiello, F., Toscano S., Ingallina C., Siler M., Cucchi D., Po A., Miele E., D’Amico D., Canettieri, G., De Smaele, E., Ferretti, E., Screpanti, I., Uccello Barretta, G., Botta, M., Botta, B., Gulino, A., and Di Marcotullio, L. Gli1/DNA interaction is a druggable target for Hedgehog‐dependent tumors. EMBO Journal 2015 34(2), pp. 200-217.

38. Uccello-Barretta, G., Balzano, F., Aiello, F., Vanni, L., Mori, M., Menta, S., Calcaterra, A., Botta, B.. Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(d-leucyl-d-valinamido) resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach. Organic & Biomolecular Chemistry 2015, 13(3), pp. 916-924.