Seminar - Marcello D'Amelio - 22/9/2020
"LOSS OF CONNECTIVITY IN MESOLIMBIC DOPAMINE PATHWAY IN EARLY ALZHEIMER's DISEASE: FROM ANIMAL MODELS TO HUMAN DISEASE"
by Prof. Marcello D’Amelio (Università Campus Biomedico; Laboratorio di Neuroscienze Molecolari CERC Fondazione Santa Lucia, IRCCS)
What happens early in the brain developing Alzheimer’s Disease (AD) still remains to be elucidated, and this is one reason why effective AD treatments are missing. In the webinar, Prof. Marcello D’Amelio will present and discuss recent experimental and clinical studies showing that the degeneration of the dopaminergic neurons in the ventral tegmental area may affect functional connectivity in the reward systems as one of the first events occurring in AD. Results of those studies may motivate future clinical trials testing new biomarkers of functional connectivity in ascending dopaminergic systems and innovative interventions to restore those systems and maybe prevent or slow down the AD neuropathology.
Prof. D’Amelio is Full Professor in Physiology and leads the Molecular Neuroscience Laboratories of the University “Campus Biomedico” (Rome, Italy) and Institute for Scientific Research and Care "S. Lucia" (Rome, Italy). His research group uses models and experimental procedures to characterize molecular, biochemical, and functional alterations that occur due to aging, age-related neurodegenerative diseases, or brain damage. Those procedures are applied to the study of several brain pathologies with a special emphasis for Alzheimer's and Parkinson's diseases.
Venue: Monday september 22th, 3.00 PM