Neuroscience

Davide Ragozzino

University position

Professore ordinario

Email

davide.ragozzino@uniroma1.it

Department

Dipartimento di Fisiologia e Farmacologia- CRiN

P.le A. Moro 5, Roma

Interests

One of my long-standing interests lies in the modulatory role of chemokines in synaptic transmission. I am coordinating a research group with extensive experience in studying the role CX3CL1 signaling in synaptic plasticity and using this expertise to address questions related to microglia functions and to the impact of microglia on synapses in physiology and pathology. I am using advanced electrophysiological, fluorescence and confocal analysis in hippocampal slices from mice defective in neuron-microglia signaling, to understand the contribution of microglia-neuron interactions.

Research keywords

AMPA receptor, ATP, Chemokine, Excitatory synaptic transmission, Fractalkine, GABA, Glia, Glutamate, microglia, Plasticity, Synaptic transmission

Research theme(s)

Cellular and Molecular Neuroscience, Developmental Neuroscience

Application fields

Neurodegeneration, Neuroimmunology, Neurophysiology

Equipment

Calcium imaging, Confocal Microscopy, Electrophysiology

Featured articles

CX3CL1-induced modulation at CA1 synapses reveals multiple mechanisms of EPSC modulation involving adenosine receptor subtypes on JOURNAL OF NEUROIMMUNOLOGY	2010
Activity of Adenosine Receptors Type 1 Is Required for CX3CL1-Mediated Neuroprotection and Neuromodulation in Hippocampal Neurons. on JOURNAL OF IMMUNOLOGY	2008
Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory on PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA	2006
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons on THE JOURNAL OF NEUROSCIENCE	2006
Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices. on NEUROPHARMACOLOGY	2006
Abnormal GABAA receptors from the human epileptic hippocampal subiculum micro-transplanted to Xenopus oocytes on PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA	2005
Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurons on THE JOURNAL OF PHYSIOLOGY	2005
Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy on PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA	2005
Phosphatase inhibitors remove the run-down of GABAA receptors in human epileptic brain. on PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA	2004
SDF-1a-mediated modulation of synaptic transmission in rat cerebellum on EUROPEAN JOURNAL OF NEUROSCIENCE	2000