Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics
Prof. Michael Higley
Dept. of Neuroscience, Yale University
April 8, 2026
Ore 14:00 - Aula Cerquiglini - CU027
Abstract
Animals regularly learn to associate sensory cues with salient outcomes. In mice, fear conditioning induces a significant increase in visually evoked cortical activity mediated by an experience-dependent enhancement of acetylcholine release in V1. Cholinergic plasticity represents a novel mechanism for learning-dependent reconfiguration of cortical networks.
