Title: “Microenvironmental control of hematopoietic regeneration”
Abstract:
Hematopoietic microenvironment, or niche, protects hematopoietic stem cells from the deleterious effects of aging and stress on hematopoietic regeneration. However, little is known about specific molecules that mediate this effect. This talk will introduce spatially-resolved single cell RNA-Seq analysis platform for niche factor discovery and describe novel regulators of hematopoietic stem cell quiescence and self-renewal which have been identified using this approach.
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