Center for Research in Neurobiology 'Daniel Bovet'

My scientific interest focuses on the neural and molecular basis of synaptic plasticity and its role in learning and memory. In this context, I investigate the interplay between physiological and environmental factors and their impact in mental health. The study of the mechanisms through which these factors interact to modulate synaptic function and plasticity is relevant for the prevention and treatment of neurodevelopmental, neuropsychiatric and neurodegenerative diseases. My current projects are mainly focused on the study of the role of microglial cells in the regulation of synaptic plasticity, learning and memory in physiological and pathological conditions in rodent models. Other projects investigate the mechanisms by which drugs of abuse, social interaction or stress influence synaptic plasticity mechanisms and neural circuits underlying behavior. My multidisciplinary approach combines behavioral studies, electrophysiological techniques (whole-cell patch clamp), molecular and immunohistochemical techniques in rodents. I follow up on correlative measures of neuronal activity with causal demonstrations with intracranial injections of pharmacological agents, messenger RNA interference, or state-of-the-art chemo-genetic DREADD methods.