Seminar: Neuron-glia metabolic coupling mediated by lactate: roles in plasticity, memory and neuroprotection - Pierre Magistretti - 11/11/2021
Distinguished Professor PIERRE MAGISTRETTI
King Abdullah University of Science and Technology (Saudi Arabia)
Neuron-glia metabolic coupling mediated by lactate:
roles in plasticity, memory and neuroprotection
Thursday, November 11th - 10:00 am
Aula RM111 - Aula Magna, Edificio C, Regina Elena
Viale Regina Elena 295, Roma
Topic of the Lecture
Glial cells have long been considered as a supporting cast for the neuronal cells. Beginning with Ramon y Cajal’s intricate illustrations over 100 years ago, neurons have commanded center stage.
Magistretti’s work has played a leading role in redefining our understanding of the brain’s systems, and by studying the full spectrum of the brain’s processes his lab has begun to chip away at the mystery of glial function. Magistretti and Pellerin presented the framework of their hypothesis in 1996, and have since then further developed and refined what has become one of the prevailing contemporary viewpoints of neuroenergetics: the Astrocyte-Neuron Lactate Shuttle (ANLS) hypothesis. The hypothesis states that astrocytes respond to intensified neuron activity by increasing their rate of glucose uptake, glycolysis and the release of lactate into the extracellular space.
Budding off their work, receptors modulated by lactate in the brain have been identified and a number of genes implicated in this phenomenon. Interference with the ANLS system has remarkable implications on delicate processes, such as long-term memory and drugs addiction. It suddenly becomes a tool we can use to modulate behaviors.
Magistretti will talk about these findings, their importance for understanding the origin of the signals detected by functional brain imaging, and how they reveal the role played by astrocytes in neuronal plasticity and neuroprotection.
Anti-COVID regulations and Registration
The event will be held according to anti-COVID regulations; valid vaccination certificate (green pass) is required in order to access to the room.
Participation is open but seats are limited; reservation is highly recommended by filling the form available at the following link.