Polycomb, Inheritance and Disease. Danny Reinberg - 6/09/19
6 Settembre 2019, ore 11.00
Danny Reinberg (Department of Biochemistry and Molecular Pharmacology NYU School of Medicine, New York, NY, USA http://reinberglab.com/)
"Polycomb, Inheritance and Disease"
Epigenetics encompasses changes in gene expression profiles that occur without alterations in the genomic DNA sequence of a cell. This arises from the dynamic processes that structure regions of chromosomal DNA through a range of compaction in eukaryotes. The altered pattern of gene expression is pivotal to cellular differentiation and development and is inherited by daughter cells thereby maintaining the integrity, specifications, and functions for a given cell type. Aberrancies in this epigenetic process give rise to perturbations that are also inherited and disruptive to normal cellular properties.
CNR Seminar Room (EMBL Rome, Adriano Buzzati-Traverso Campus, Via Ramarini 32, 00015 Monterotondo, Italy)