Role of Poly(ADP-ribose) metabolism in DNA repair and Cancer. Guy Poirier - 27/09/19
27 Settembre 2019, ore 12.00
Guy Poirier (Università Laval- Quebec Canada)
"Role of Poly(ADP-ribose) metabolism in DNA repair and Cancer"
The PARP field has undergone many important developments in the last ten years. Firstly, PARP inhibitors have been the first in class drugs applying the principle of synthetic lethality in DNA repair homologous recombination deficient cancers. The main tumors being targeted are ovary, breast and prostate cancers. There are more than 600 clinical trials at the moment testing the potency of PARP inhibitors in various types of cancers. Also PARP-1 and PARP-2 have been shown to be involved in cell death of neurons and in the brain: PARTHANATOS.
Finally this talk will address the latest developments in proteomics to analyze covalent and non-covalent poly(ADP-ribose) modifications. Also the latest results in the function of PARP-1 in homologous recombination will be described.
This research was supported by CIHR, Genome Canada, FRQS, NIH and CFI.
Aula A (CU010) Dipartimento di Scienze Biochimiche