DepartmentDipartimento di Fisiologia e Farmacologia
My research interest concerns neuron-neuron and neuron-glia signalling and its regulation in physiological and pathological conditions.
My main focus is on the role of ionotropic receptors, from the single-channel to the network level.
In particular, I am interested in:
i) the glutamatergic and GABAergic signalling and the excitation-inhibition balance of neurons (AD; ALS: AriSLA Pilot Grant 2012)
ii) the biocompatibility of engineered silicon- or carbon- derived nano-structures
iii) the pharmacological modulation of ligand-gated ion channels
For my studies I primarily use patch-clamp techniques to investigate native (brain slices or cells in culture) or recombinant ion channels. Further approaches are: retrograde labelling, ultra-fast concentration jumps, live-imaging and molecular biology techniques.
Formerly, I have worked:
with Prof. SG Cull-Candy and Prof M Farrant at the Neuroscience, Physiology and Pharmacology Dept., University College London (UK; postdoctoral);
with Prof F Eusebi at the Dept of Physiology and Pharmacology, Sapienza University (PhD training); and,
with Prof G Levi and Dr S Visentin at the Patho-Physiology Dept, Ist. Sup. di Sanità (I; predoctoral training).
My current collaborators include:
Prof M D’Amelio
(Campus Bio-medico University & IRCCS Santa Lucia; Rome, I)
Cortical and sub-cortical alterations in the Tg2576 mouse model of Alzheimer Disease
Prof F Palma
(SBAI Sapienza University; Rome, I)
Biocompatibility of engineered nano-structures
Prof S Fucile
(Physiol. & Phamac. Dept Sapienza University; Rome, I)
Functional and pharmacological properties of LGICs
Prof D Ragozzino and Prof R Ventura
(Physiol. & Phamac. Dept & Psycology Dept Sapienza University; Rome, I)
Alteration of excitability in sub-cortical networks related to stress and behaviour