Surname

Babiloni

Name

Claudio

Position

Full Professor

Subject

Bio09 - Physiology

Department

Department of Physiology and Pharmacology “V. Erspamer”

e-mail

claudio.babiloni@uniroma1.it

Twitter

@BabiloniClaudio

YouTube Channel

https://www.youtube.com/channel/UCJF6bAQkFcPFt8vHcLRy9-Q

Web

https://www.pdwaves.eu/

No.

PubMed papers

1.

BABILONI C, Barry RJ, Başar E, Blinowska KJ, Cichocki A, Drinkenburg WHIM, Klimesch W, Knight RT, Lopes da Silva F, Nunez P, Oostenveld R, Jeong J, Pascual-Marqui R, Valdes-Sosa P, Hallett M. International Federation of Clinical Neurophysiology (IFCN) - EEG research workgroup: Recommendations on frequency and topographic analysis of resting state EEG rhythms. Part 1: Applications in clinical research studies. Clinical Neurophysiology. Clin Neurophysiol. 2020 Jan;131(1):285-307. doi: 10.1016/j.clinph.2019.06.234. Scopus All Metrics: Field-Weighted citation impact of 5.33; 100 citations and 97th percentile; Views count 2014-2023 of 120.

2.

Babiloni C., Lopez S., Del Percio C., Noce G, Pascarelli MT, Lizio R, Teipel S, González-Escamilla G, Bakardjian H, George N, Cavedo E,  Lista S, Chiesa PA, Vergallo A., Lemercier P, Spinelli G, Grothe M, Potier M, Stocchi F, Ferri R, Habert M, Fraga F, Dubois B, Hampel H. Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study. Neurobiology of Aging, 2020, 90, pp. 43–59. Scopus All Metrics: Field-Weighted citation impact of 2,21; 21 citations and 89th percentile; 73 of Views count 2014-2023.

3.

BABILONI C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, Dubois B, Escudero J, Fernández A, Frisoni G, Guntekin B, Hajos M, Hampel H, Ifeachor E, Kilborn K, Kumar S, Johnsen K, Johannsson M, Jeong J, LeBeau F, Lizio R, Lopes da Silva F, Maestú F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Olichney J, Onofrj M, Palop JJ, Rowan M, Stocchi F, Struzik ZM, Tanila H, Teipel S, Taylor JP, Weiergräber M, Yener G, Young-Pearse T, Drinkenburg WH, Randall F. What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons. Neurobiol Aging. 2020 Jan;85:58-73. doi: 10.1016/j.neurobiolaging.2019.09.008. Epub 2019 Sep 19. Scopus All Metrics: Field-Weighted citation impact of 4.54; 91 citations and 96th percentile; 192 of Views count 2014-2023.

4.

BABILONI C, Lizio R, Marzano N, Capotosto P, Soricelli A, Triggiani AI, Cordone S, Gesualdo L, Del Percio C. Brain neural synchronization and functional coupling in Alzheimer's disease as revealed by resting state EEG rhythms. Int J Psychophysiol. 2016 May;103:88-102. doi: 10.1016/j.ijpsycho.2015.02.008.  Scopus All Metrics: Field-Weighted citation impact of 3.22; 193 citations and 93th percentile; 174 of Views count 2014-2023.

5.

Teipel S, Grothe MJ, Zhou J, Sepulcre J, Dyrba M, Sorg C, BABILONI C. Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications. J Int Neuropsychol Soc. 2016 Feb;22(2):138-63. doi: 10.1017/S1355617715000995. Scopus All Metrics: Field-Weighted citation impact of 5.27; 78 citations and 97th percentile; 97 of Views count 2014-2023.

No.

Titolo progetto

Ente finanziatore

Ruolo (PI, co-PI, partecipante)

Anno inizio / fine

1.

Peripheral Biomarker Based Combinatorial Early Diagnostics for Dementia (CombiDiag). Funding for the University of € 259,437.60.

HORIZON 2021, H2021-MSCA-DN-2021 (Marie Skłodowska-Curie Doctoral Networks). Proposal number: 101071485

Responsabile scientifico di Unità operativa di UNIROMA1

2023/2027

2.

Interdisciplinary digital twins for modelling and simulating complex phenomena at the service of research infrastructure communities). Funding of € 381,245.

HORIZON 2021, HORIZON-INFRA-2021-TECH-01 (HORIZON-INFRA-2021-TECH-01-01 - Grant Agreement: GAP-101058516

Responsabile scientifico di Unità operativa di UNIROMA1

2022/2026

3.

Blood Biomarker-based Diagnostic Tools for Early-Stage Alzheimer’s Disease (BBDiag). Funding of € 495,448.64.

HORIZON 2020, H2020-MSCA-ITN-2016 (Marie Skłodowska-Curie Innovative Training Networks; MSCA-ITN-ETN)

Grant Agreement: 721281

Responsabile scientifico di Unità operativa di UNIROMA1

2017-2020

4.

Title of the project: Diagnostic enhancement of confidence by an International distributed environment. Funding of € 148,000.

Call and Sponsor: EUROPEAN COMMISSION 7TH FRAMEWORK PROGRAMME CAPACITIES - RESEARCH INFRASTRUCTURES CALL IDENTIFIER: FP7-INFRASTRUCTURES-2010-2. Grant Agreement: RI-261593

Responsabile scientifico di Unità operativa di UNIFG

2010/2013

5.

Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in early clinical development. Funding of € 568,000

Call and Sponsor: EUROPEAN COMMISSION 7TH FRAMEWORK PROGRAMME IMI Call topic: IMI_Call_2008_1_11: Neurodegenerative Disorders IMI-1 Joint Undertaking. Grant Agreement: 115009

Responsabile scientifico di Unità operativa di UNIFG

2010/2016

No.

Surname

Name

Department

1

Prof. Babiloni, PhD

Claudio

Department of Physiology and Pharmacology “V. Erspamer”

2

Prof. Del Percio, PhD

Claudio

Department of Physiology and Pharmacology “V. Erspamer”

3

Dr. Onorati, Neurologist

Paolo

Department of Physiology and Pharmacology “V. Erspamer”

4

Dr. Lizio, PhD

Roberta

Department of Physiology and Pharmacology “V. Erspamer”

5

Dr. Lopez, PhD

Susanna

Department of Physiology and Pharmacology “V. Erspamer”

6

Dr. Tucci, PhD

Federico

Department of Physiology and Pharmacology “V. Erspamer”

7

Prof. Giubilei, Neurologist

Franco

NESMOS

8

Dr. Noce, PhD

Giuseppe

IRCCS SDN of Naples

The Lab of "High-Resolution EEG and Neurophysiology of Higher Functions"

The Lab aims to offer theoretical and experimental advice in the development and validation of neurophysiological biomarkers of cortical neural synchronization and functional connectivity. These biomarkers could be diagnostic or prognostic, monitoring and evaluating the efficacy of pharmacological or nonpharmacological interventions for brain diseases or infections affecting the brain and associated with deficits in the sleep-wake cycle, vigilance in wakefulness and cognitive functions over the life span.

The Lab has a soundproof and electrically shielded chamber and a system for recording electroencephalographic (EEG), electrooculographic (EOG), electromyographic (EMG), and electrocardiographic (ECG) signals, as well as measures of skin impedance, respiration, and blood oxygenation. Recording of these signals can be done before, during, and after magnetic and transcranial electrical stimulations to modulate the excitability of cortical regions. Neurophysiological biomarkers can be derived from the recording of the aforementioned signals under conditions of quiet wakefulness (resting state), drowsiness and sleep, processing of visual and auditory stimuli in tasks involving attentional, perceptual, short- and long-term memory, and decision-making processes.  

The Lab can be of interest to support the development of state-of-the-art simulations of brain electrophysiological signal generation (e.g., local field potentials, EEG) for developing digital brain twin models for research and clinical applications. These brain twin models are typically based on artificial intelligence techniques and mathematical models of the structure and function of ascending subcortical neuromodulation systems and thalamocortical and cortico-cortical systems.

The Open Lab can also be of interest to research groups, large (pharmaceutical, biotech industries), medium-sized, small, and start-up companies that need to carry out experimental campaigns and advanced simulations for scientific purposes or for the development of pharmacological and nonpharmacological interventions, including functional foods, dietary supplements, herbal products, non-invasive brain stimulation, and healthy lifestyles.

The Open Lab is located in Building Cu027 and Building Cu026, in the place of the Department of Physiology and Pharmacology "V. Erspamer." It can rely on a Team consisting of professors, researchers, post-docs, and doctoral fellows working on the clinical application of the above neurophysiological biomarkers on patients with neurodegenerative diseases of aging (e.g., Alzheimer's disease, Parkinson's disease, Lewy body disease, frontotemporal disease, Huntington's chorea) and neurological complications of HIV infections and covid-19).

EN

Facilities for enrolment and data collection of neurological patients

The Neurology Unit at the Sant ‘Andrea Hospital of the Sapienza University of Rome, directed by Prof. Franco Giubilei, for the enrolment of neurological patients and collection of biochemical, clinical, neurological, neuroimaging, and EEG data in hospital settings.

Facilities for data recording in the Open Lab

N. 1 BRAINPRODUCT BRAIN VISION recording system of high-resolution EEG and 64-channel EOG, ECG, and EMG controls, compatible with transcranial magnetic stimulation (TMS) and electric current stimulation.

N. 1 NEXUS MINDMEDIA recording system of skin impedance, oximetry, and respiratory rate.

N. 1 MAGSTIM RAPID 2 repetitive and dual-stimulus TMS system.

N. 1 EMS BrainSTIM+ transcranial alternating electrical stimulation system.

N. 1 PRESENTATION software for the sensory stimulus delivery and behavioral response recording system.

Hardware and software resources for data analysis and representation

- N. 10 workstations with state-of-the-art tower computers for quantitative analysis of EEG, EOG, EMG, skin impedance, respiratory rate, and blood oxygenation signal;

- N. 10 eLORETA (https://www.uzh.ch/keyinst/loreta) and EEGLab. (https://sccn.ucsd.edu/eeglab/index.php) platforms for the frequency and spatial analysis of cortical sources of EEG signals and for the quantitative analysis of EOG, ECG, and EMG signals.