John Russo, "SATisfaction guaranteed: Inverse Self-Assembly as a Colouring Problem", Dip. di Fisica
Seminari del vincitore e della vincitrice ex aequo della procedura selettiva professore di I fascia - SSD PHYS-04/A (EX SSD FIS/03) CODICE CONCORSO 2024_POcomma4ter_001.
Oratore: John Russo. Aula: Rasetti edificio Marconi (CU013).
Titolo: "SATisfaction guaranteed: Inverse Self-Assembly as a Colouring Problem".
Abstract: The ability to assemble complex structures from elementary components has been a central goal of nanotechnology ever since Feynman posed the question: “What would happen if we could arrange the atoms one by one the way we want them?” Self-assembly, the process by which components spontaneously organize into ordered structures, has emerged as the most promising approach to achieving this vision. Inspired by its ubiquity in biological systems, nanotechnology has long sought to harness self-assembly for the bottom-up design of materials with tailored optical, mechanical, and other functional properties. However, the inverse self-assembly problem, i.e. determining the inter-particle interactions required to assemble a given target structure, remains a fundamental challenge.
In this seminar, I will present our advancements in tackling the inverse self-assembly problem. I will introduce the SAT-assembly method [1], where interaction rules between building blocks are discovered by solving Boolean satisfiability (SAT) problems. This approach allows for the systematic design of self-assembling systems by incorporating additional constraints, such as the non-satisfiability of competing structures [1], the presence of azeotropic points [2], and two-step nucleation mechanisms [3]. These conditions enable precise control over the assembly pathway and lead to a significant increase in yield. I will showcase examples of successful assemblies, from photonic crystals [4] to capsids [5], demonstrating applications both in silico and in vitro.
References
[1] J Russo, F Romano, L Kroc, et al., J. Phys. Cond. Matt. 34, 354002 (2022)
[2] C Beneduce, F Sciortino, P Šulc, J Russo ACS Nano 17, 24841 (2023)
[3] C Beneduce, D Pinto, P Šulc, et al., J. Chem. Phys., 158, 154502 (2023)
[4] H Liu, M Matthies, J Russo, L Rovigatti, et al., Science 384, 776 (2024)
[5] D Pinto, P Šulc, F Sciortino, J Russo, PNAS 120, e2219458120 (2023)
Per coloro che fossero impossibilitati ad essere presenti vi è la possibilità di seguire tramite il collegamento zoom dell'aula: https://uniroma1.zoom.us/j/85078619957?pwd=R3VkcDNCZXB3dW5uaE5NamxvbDd5dz09.
